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[KnowledgeExchange] 求合作包发paper!Adaptation without Feedback or Feedforward

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IP  110.96.32.166

Posted at 2013-9-12 17:13:35 | All floors |Read mode
Last edited by zhiyuanli In 2013-9-14 12:08 Editor

大家好,我是汤超老师组的志远,对于数学建模比较熟悉,之前有过一篇JTB和一篇Cell。现在我这里有个应该至少能在三个月内发个小paper的理论project,非常需要人合作

project介绍:
概括:Adaptation without Feedback or Feedforward
背景知识:前人认为,Biological adaptation 只能在有负反馈(negative feedback loop)或者前馈(incoherent feedforward)的情况下出现 (马文喆学长的三节点穷举牛paper!)。然而,这些之前的工作都将目光限定在蛋白作用网络或者转录调控网络中。如果将转录调控和蛋白质作用结合起来,就可以在网络没有任何反馈和前馈的情况下实现perfect adaptation (我已经做了理论分析 )

为什么要现在做:之前我在本科生科研的时候就已经注意到这个现象并做了分析,但当时我和老板们都觉得这个机制不太可能在实际中发生就没有去管它。结果……刚刚有人已经把实验做出来了并且发了Nature ( 文章看这里 )。再不做理论就晚了
为什么要找人合作:我要毕业事情太多做不完啊啊啊啊,写paper太花时间了

希望合作者:
有时间投入,我希望未来三个月内能搞定它。
有一定的英文基础(paper主要是你写,嗯)并能快速阅读前人paper
对生物有一定知识,至少知道蛋白相互作用,转录,降解的基本原理。
对非线性要求会稳态分析就好了(上过欧阳老师的非线性就应该足够了)

有合作意向的,请读一下附件的两篇pdf(一篇是我之前做的数据分析,一篇是我说的那篇实验文章),然后通过我的gmail:zhiyuanli.g1_at_gmail.com,或者qq找我。

你会是共同第一作者 谢谢~



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给我一块二向箔,清理用

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Posted at 2013-9-13 13:55:53 | All floors
Last edited by ltt In 2013-9-14 02:42 Editor

看上去很有意思的样子!

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Posted at 2013-9-14 10:49:10 | All floors
nah...  I don't have enough money to download the twp papers.

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Posted at 2013-9-14 12:10:02 | All floors
YAN_xiaodong Posted at 2013-9-14 10:49
nah...  I don't have enough money to download the twp papers.

Actually you already had enough money after you replied the post.... every post replying gives you 2 credits

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Posted at 2013-9-19 11:40:26 | All floors
am i  too late....
sounds interesting .

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IP  162.105.60.102

Posted at 2013-9-19 16:15:43 | All floors
one paper has discussed this mofit, but their point is the evolution.

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IP  162.105.60.102

Posted at 2013-9-19 16:21:49 | All floors
And  they studies always focus on protein binding. like oscillation, bistability.

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 Author| Posted at 2013-9-20 04:31:39 | All floors
Last edited by zhiyuanli In 2013-9-20 04:34 Editor

多谢paper!佳佳我们来做吧~
给我一块二向箔,清理用

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Posted at 2013-9-21 14:18:59 | All floors
Great deal...I will try to read the paper.

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Posted at 2013-9-21 17:05:55 | All floors
aruonijiao Posted at 2013-9-14 12:10
Actually you already had enough money after you replied the post.... every post replying gives you ...

I appreciate that!

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