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Author: zhiyuanli

[Challenge Topic] Evolving out of cancer (Matt Thomson, Simone Bianco, Zhiyuan Li)

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IP  124.193.192.11

Posted at 2012-5-15 22:56:56 | All floors
so far, we, in my department, have synthesized PI3K m-TOR, EGFR inhibitors, and the Biomodel suggests effective on mice.

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IP  124.193.192.11

Posted at 2012-5-15 23:11:25 | All floors
With a  known mechanisms of cancer, it is easy to find out the reliable target(s),designing  new drugs to treat the cancer is not far away, I am looking forward to that network coming true.

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IP  162.105.160.198

Posted at 2012-5-16 16:14:10 | All floors
Hello, I remember that at the discussion on Sunday, someone(sorry, I don't know your name yet) showed a literature published on Cell recently, which is about the evolution of cancer. It seems to be interesting, but unfortunately I have forgotten its title... Who can tell me this? thanks a lot~

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His name is Zhu Junhao. I'll write a letter to ask the name of paper that he showed.  Posted at 2012-5-15 09:48

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IP  162.105.160.198

Posted at 2012-5-16 16:33:02 | All floors
Reply YuanYuan Add Thread

I guess Chang means we can give some assumptions about the evolution process, for example, constant mutation rate and fixed form of environmental pressure. Of course we can run some simulations based on our assumptions and compare the result with experimental data, but I'm doubtful about whether we can get meaningful conclusions if the model we used is too simplified.


   

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IP  162.105.160.33

Posted at 2012-5-14 18:39:28 | All floors
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replicative: cells have their limit for devision(termed Hayflick limit), they stop repllicat ...
Amber.Zw.W replied at 2012-5-12 20:58

I agree with that age is a matter of “structural and functional degeneration”.  But what I disagree is that aging is not a matter of time... I think time information just hides behind the  “structural and functional degeneration”. Otherwise, biological system would not remember what state it is in, what to do in the next step and eventually every organism will be immortal... The reason that some people live long is that their "clock" is slower than the rest of us. Maybe the clock rate is related to the metabolic system.One of my undergraduate professor studies on the micro-environment around tumor cells and changing the environment dose work.

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Posted at 2012-5-14 23:42:06 | All floors
ask a small question: what kinds of animals can have cancer?

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IP  162.105.23.227

Posted at 2012-5-15 09:53:15 | All floors
Reply ziwei Add Thread


    Someone will introduce the background of cancer drug resistance. maybe everything will be redefined after we know the background.

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It seems to be a little weird. This post should be at the Page 3, after ziwei's post. However, as the system clock for the server was modified, it now is at Page 2, just before my previous post that   Posted at 2012-5-15 09:59

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IP  222.29.46.51

Posted at 2012-5-15 10:07:37 | All floors
Reply ziwei Add Thread


    So what do our assumptions base on? Maybe on one hand, it can be based on the so-far known mechanisms or datas, but on the other hand, we are supposed to carry out some new mechanisms for the so-far known mechanisms are incomplete. So my question is how to achieve these by experiment on computers?

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IP  162.105.40.56

Posted at 2012-5-15 23:27:23 | All floors
Reply ChangChang Add Thread


   One important thing about modeling is that we have to consider what sets of data we should use. At least we should know whether these data are about detailed molecular interaction (such as binding coefficients or reaction rates...) or about the sequence (such as mutation rate, GC content...), because the model is depend on the data we select.

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IP  162.105.160.226

Posted at 2012-5-16 09:34:23 | All floors
Reply tqli Add Thread


    for microbes, there exist other mechanisms. The persister cells has some genes related to their resistance of antibiotics, such as hipA. Other perstisters slow down their growth rate so that some antibiotics can not act on DNA replication. as cancer divides fast, I have no idea if cancer cells have some genes that regulate their growth rate and escape the drugs.

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IP  162.105.23.86

 Author| Posted at 2012-5-16 16:20:34 | All floors
为什么最新的回复不显示?奇了怪了……
给我一块二向箔,清理用

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IP  162.105.23.162

 Author| Posted at 2012-5-16 17:39:00 | All floors
ya now everything returns to normal....
给我一块二向箔,清理用

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IP  162.105.160.21

Posted at 2012-5-16 17:49:11 | All floors
I found something on Science Signaling Editor's Choice which may help us to develop this topic.

"Rewiring the Networks" by John F. Foley
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/224/ec135


    It shows that "Chemotherapeutic agents that induce the DNA damage response (DDR) are typically used to kill tumor cells; however, the effects of aberrant growth factor signaling, for example, can lead to resistance." And it also mentions that triple-negative breast cancer (TNBC) cells respond poorly to standard therapies.
    Microarrays and Western blotting analysis were used to construct mathematical models to describe the cellular phenotypes. Some models predicted some interesting thing.
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