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system biology for Cancer

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Posted at 2018-1-19 22:19:21 | All floors |Read mode
Last edited by Shuonan_Wu In 2018-1-19 22:38 Editor

首先介绍一下我们的组员:   组长:吴姝芳(2017CQB 物理)
   队员:吴结根(2016CLS 生物工程/生物信息)
             张剑寒(2016CQB 物理)
             杨婷玉(2017CLS 生物)
             韩旭   (2017CLS 生物)
             秦宸睿(2018CLS 生物技术)
             史安腾(2014本科 临床医学)
             武朔南(2017本科 整合科学)


主题:癌症系统生物学

以下是我们初期拟定的几个主题:




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 Author| Posted at 2018-1-19 22:43:17 | All floors

第一次讨论:12.24 10:00-12:00
地点:老化学楼 102
迈上了漫漫的确定主题的道路

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 Author| Posted at 2018-1-19 22:53:45 | All floors
Shuonan_Wu Posted at 2018-1-19 22:43
第一次讨论:12.24 10:00-12:00
地点:老化学楼 102
迈上了漫漫的确定主题的道路

第二次讨论:
综合科研楼425   讨论时间12.31 10:00-12:00

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 Author| Posted at 2018-1-19 22:54:41 | All floors
Shuonan_Wu Posted at 2018-1-19 22:53
第二次讨论:
综合科研楼425   讨论时间12.31 10:00-12:00

附上第二次讨论照片pdf文件http://cqb.pku.edu.cn/bbs/forum.php?mod=attachment&aid=MzI4fGMxNjUyMjFjNWY1ZmEwZWIzZTk3Y2Y3MmM2NTg1MTVhfDE1Mjk3MDk0MzM%3D&request=yes&_f=.pdfattach://328.pdf

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 Author| Posted at 2018-1-19 23:02:17 | All floors
第三次讨论1.6中期汇报之前大家一起讨论答辩内容




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 Author| Posted at 2018-1-22 11:26:32 | All floors
Shuonan_Wu Posted at 2018-1-19 23:02
第三次讨论1.6中期汇报之前大家一起讨论答辩内容

第四次讨论时间:1.14 10:-12::0



确定了5k字报告的大致内容与逻辑框架。
进一步细致调研文献

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 Author| Posted at 2018-1-22 11:29:17 | All floors
Shuonan_Wu Posted at 2018-1-22 11:26
第四次讨论时间:1.14 10:-12::0

第五次讨论1.19  晚7点——很晚
地点老化学楼302


为了赶报告,组员买了许多零食。

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 Author| Posted at 2018-1-22 11:39:19 | All floors
Shuonan_Wu Posted at 2018-1-22 11:29
第五次讨论1.19  晚7点——很晚
地点老化学楼302

第六次讨论:关于ppt修改&练习     时间1.21  18:00-20:00 老化学楼302
另外还整理了文献

图为   练习报告



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 Author| Posted at 2018-1-22 11:49:00 | All floors
Shuonan_Wu Posted at 2018-1-22 11:39
第六次讨论:关于ppt修改&练习     时间1.21  18:00-20:00 老化学楼302
另外还整理了文献

以下是我们的参考文献:
1. Ganly I, Kirn D, Eckhardt G, et al. A phase I study of Onyx-015, an E1B attenuated adenovirus, administered intratumorally to patients with recurrent head and neck cancer.[J]. Clinical Cancer Research An Official Journal of the American Association for Cancer Research, 2000, 6(3):798-806.
2. Alemany R, Balagué C, Curiel D T. Replicative adenoviruses for cancer therapy[J]. Nature Biotechnology, 2000, 18(7):723-7.
3. Cancer A A F. Clinical cancer research : an official journal of the American Association for Cancer Research[M]. The Association, 2013.
4. Heise C, Hermiston T, Johnson L, et al. An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy.[J]. Nature Medicine, 2000, 6(10):1134-9.
5. Fukuda K, Abei M, Ugai H, et al. E1A, E1B double-restricted adenovirus for oncolytic gene therapy of gallbladder cancer.[J]. Cancer Research, 2003, 63(15):4434.
6. Yamamoto Y, Nagasato M, Yoshida T, et al. Recent Advances in Genetic Modification of Adenovirus Vectors for Cancer Treatment[J]. Cancer Science, 2017, 108(5):831-837.
7. Yamamoto M, Curiel D T. Current Issues and Future Directions of Oncolytic Adenoviruses[J]. Molecular Therapy, 2010, 18(2):243-250.
8. Victor Krasnykh, Igor Dmitriev, Galina Mikheeva, C. Ryan Miller, Natalya Belousova, David T. Curiel. Characterization of an adenovirus vector containing a heterologous peptide epitope in the HI loop of the fiber knob.[J]. Journal of Virology, 1998, 72(3):1844-52.
9. Liu Y, Wang H, Yumul R, et al. Transduction of Liver Metastases After Intravenous Injection of Ad5/35 or Ad35 Vectors With and Without Factor X-Binding Protein Pretreatment[J]. Human Gene Therapy, 2009, 20(6):621.
10. Douglas J T, Rogers B E, Rosenfeld M E, et al. Targeted gene delivery by tropism-modified adenoviral vectors.[J]. Nature Biotechnology, 1996, 14(11):1574.

11. Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, doi:10.1016/j.cell.2011.02.013 (2011).
12. Rama, A. R., Aguilera, A., Melguizo, C., Caba, O. & Prados, J. Tissue Specific Promoters in Colorectal Cancer. Dis Markers 2015, 390161, doi:10.1155/2015/390161 (2015).
13. Garg, H., Salcedo, R., Trinchieri, G. & Blumenthal, R. Improved nonviral cancer suicide gene therapy using survivin promoter-driven mutant Bax. Cancer Gene Ther 17, 155-163, doi:10.1038/cgt.2009.63 (2010).
14. Nissim, L. et al. Synthetic RNA-Based Immunomodulatory Gene Circuits for Cancer Immunotherapy. Cell 171, 1138-1150 e1115, doi:10.1016/j.cell.2017.09.049 (2017).
15. Hodgman, C. E. & Jewett, M. C. Cell-free synthetic biology: thinking outside the cell. Metab Eng 14, 261-269, doi:10.1016/j.ymben.2011.09.002 (2012).
16. Sonabend A M, Ulasov I V, Tyler M A, et al. Mesenchymal stem cells effectively deliver an oncolytic adenovirus to intracranial glioma.[J]. Stem Cells, 2008, 26(3):831.
17. Ran L, Tan X, Li Y, et al. Delivery of oncolytic adenovirus into the nucleus of tumorigenic cells by tumor microparticles for virotherapy.[J]. Biomaterials, 2016, 89:56.
18. Abernathy K, Abernathy Z, Baxter A, et al. Global Dynamics of a Breast Cancer Competition Model[J]. Differential Equations and Dynamical Systems, 2017: 1-15.
19. Banerjee A, Vasanthakumar A, Grigoriadis G. Modulating T regulatory cells in cancer: how close are we?[J]. Immunology & Cell Biology, 2013, 91(5):340.
20. Bandukwala H S, Wu Y, Feuerer M, et al. Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells.[J]. Immunity, 2011, 34(4):479.


以及另外一些有意思的paper,但我们没有参考。如
Zdenek Skrott, Martin Mistrik, Klaus Kaae Andersen, et al. Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4. Nature (2017). DOI: 10.1038/nature25016

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 Author| Posted at 2018-1-22 11:53:57 | All floors
Shuonan_Wu Posted at 2018-1-22 11:49
以下是我们的参考文献:
1. Ganly I, Kirn D, Eckhardt G, et al. A phase I study of Onyx-015, an E1B  ...


这篇文章讲述戒酒药抗癌的发现

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 Author| Posted at 2018-1-22 11:58:37 | All floors
Shuonan_Wu Posted at 2018-1-22 11:53
这篇文章讲述戒酒药抗癌的发现

关于最终报告中包含的一些模拟,其代码参考
https://github.com/search?utf8=% ... gillespie&type=
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