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Author: zhiyuanli

[Challenge Topic] FUTURE OF OPTOGENETICS (Jared Toettcher, Amir Mitchell)

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IP  162.105.100.165

Posted at 2012-5-30 23:09:45 | All floors
When using optogenetic tools , was the light stimulus given by outside environment manipulated by human? Maybe we can use fluorescent protein to let the cell give light by itself, although this may not be controlled accurately.

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Posted at 2012-6-1 10:09:45 | All floors
light is coming from outside with different wavelength depending on which light system we use.
you can light the cell by fluorescence, but the optogenetics we talk about here are mostly related to manipulate the cell using light.
e.g. we can use light to active or inactive proteins;
      we can use light to change the localization of proteins;
      also, we could use light to make unique cell-cell communication.
i love fluorescence which light the micro-world, and at another aspect, light(within different wavelength) would also change the micro-world.

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Posted at 2012-6-5 16:09:44 | All floors
Periodism occurs to many organsims, for example, some plant require enough light as an essential signal for development in spring, maybe we can mimic the signals by optogenetics in order to control behavior of the organsims

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Posted at 2012-6-6 14:44:30 | All floors
good point, we have another member also raised this question.
could u give us more detail information about the mechanism that how [size=-1]biorhythms works?
e.g. who is the one sensing the light signal? is there a pathway that we could draw based on paper research?
then we may try to make a fancy proposal on this point.

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Posted at 2012-6-6 20:05:16 | All floors
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    I do not know many details about it indeed, It just come to my mind suddendly, I think I can do some investigation on  research about that and try to focus on a specific phenomenon and post some information. It needs some time.

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Posted at 2012-6-6 21:29:33 | All floors
加油加油!!!
if u find great papers, pls list them here, all optoers could share and take a look.
thanks


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Posted at 2012-6-7 18:57:35 | All floors
I prepare several slides about optogenetics introduction, which may be helpful to newcomer.

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Posted at 2012-6-9 14:29:22 | All floors
We have known four or five kinds of photorecptors in plant. Researches in plant photorecptors reveal their key roles in development and periodism,  we have known some signal transduction mediated by photoreceptors whose downstream sometimes involve in transcription factor controlling many genes. Optogenetics has touched the phytochrome-PIF system, which is a well known photorecptor of plant. Attached several good review about them.

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Posted at 2012-6-21 08:43:58 | All floors
Hi everyone! I'm Jared, one of the UCSF postdocs who will be organizing this session. My research is deeply connected to one optogenetic technique in individual cells (the phytochrome system appearing in Levskaya et al 2009), so this is a topic of very personal interest to me.

It's very exciting to see everyone's interest and excellent ideas. I'll be responding to many of your ideas in the coming days, and will start thinking a little more (and posting my thoughts) about what we can accomplish during this intensive workshop!

Very much looking forward to meeting you all & seeing Beijing!

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Posted at 2012-6-21 16:56:00 | All floors
wow~~~
finally we see u!!!
waiting for ur reply

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Posted at 2012-6-23 20:27:50 | All floors
a question is whether the light tool is dose response, not only have on and off state?
if it is, then it should be more useful.

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Posted at 2012-6-25 14:09:44 | All floors
Yes, it is dose response.
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