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[Challenge Topic] MICROFLUIDICS DEVELOPMENT (Laurens Kraal, Zac Apte)

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IP  162.105.160.10

Posted at 2012-4-30 12:15:17 | All floors |Read mode
original link: http://www.ucsf-pku.org/index.php/MICROFLUIDICS_DEVELOPMENT


Grand Challenge - Develop A Microfluidics Based approach to diagnostics or vaccination to a pervasive desease.


Outcomes:1. Choice of Relevant Disease
2. Choice of approach to diagnostic or vaccine
3. Schematic of protocol to be implemented on chip
4. A roadmap/plan to develop and test the chip
5. Something like a gates grant application? (2 page detailed writeup)
Background:
         Microfluidics have the potential to bring specific lab protocols to the public in a useable manner.
Outline
  • introduction on microfluidics:
    • droplet based
    • blood on chip
    • different implementations
    • modules
  • first day first half:
    • Brainstorm about diseases/issues in 3rd world countries
    • decide on disease to tackle
  • first day second half:
    • decide on platform
  • second day:
    • what modules do we need?
    • design device
    • scalability?
    • cost analysis?
    • low tech implementation?

Homework:
  • Autocad tutorial
  • some flow calculations
  • design a device that does X, Y and Z
    • describe how to implement it (different layers, wiring/tubing, etc)
  • everyone choose a disease and read up on it (especially tropical neglected etc)


Wish List:wish list goes here

Papers:
  • Guo et al. Droplet microfluidics for high-throughput biological assays. Lab Chip (2012) pp. 1-10
  • Chen et al. Shrinky-Dink microfluidics: 3D polystyrene chips. Lab Chip (2008) vol. 8 (4) pp. 622
  • Ferry et al. Microfluidics for Synthetic Biology: From Design to Execution. Synthetic Biology, Part A (2011) vol. 497 pp. 295-372
  • Whitesides. The origins and the future of microfluidics. Nature (2006) vol. 442 (7101) pp. 368-373
  • Northrup. Microfluidics: a few good tricks. Nature Materials (2004) vol. 3 (5) pp. 282-283
  • Toner and Irimia. Blood-on-a-chip. Annu. Rev. Biomed. Eng. (2005) vol. 7 pp. 77-103
  • Brody et al. Biotechnology at low Reynolds numbers. Biophysical Journal (1996) vol. 71 (6) pp. 3430-3441
  • Rhee, M., & Burns, M. A. (2008). Microfluidic assembly blocks. Lab on a Chip, 8(8), 1365. doi:10.1039/b805137b
给我一块二向箔,清理用

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IP  162.105.160.35

Posted at 2012-5-8 14:55:16 | All floors
grand challenge 也有一个做vaccine的 当时他们来北大宣传的时候说 很多都没有注射疫苗 如果能让疫苗变得和可口可乐一样深入到世界各个角落就好了...
FIGHT

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 Author| Posted at 2012-5-9 16:41:11 | All floors
Reply Zairan Add Thread

Then you have to make the vaccine tasty or be able to cook chicken wing~

   
给我一块二向箔,清理用

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Posted at 2012-5-9 21:15:00 | All floors
every coke cure thirst

how about vaccine...

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IP  162.105.103.133

Posted at 2012-5-15 13:53:56 | All floors
why this topic is deserted~~

Reviews

so share ur opinion on it, and more will come~^0^  Posted at 2012-5-15 21:24

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IP  124.128.37.18

Posted at 2012-5-15 21:26:11 | All floors
怎么这个topic就跑到yummy上面去了~
王紫薇

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IP  162.105.248.40

Posted at 2012-5-23 10:15:46 | All floors
吃货=master of eating

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IP  162.105.11.34

Posted at 2012-5-26 10:56:18 | All floors
为啥这个帖子的内容看着这么奇怪呢?~为什么会选中这个题目的~~

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IP  162.105.103.4

Posted at 2012-5-27 13:26:58 | All floors
求做这个题目的同仁啦~~~
@李黎~~

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IP  202.66.131.115

Posted at 2012-5-28 18:59:22 | All floors
Reply songdaidai Add Thread


    I'm here~~

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IP  162.105.103.87

Posted at 2012-5-28 23:58:17 | All floors
And in my opinion, even though the topic of microfluidics development seems so big, when we choose a specific disease like cancer, the experiments can be realized in lab. Because cancer is really a important disease, and many people are interested in it.

Link of LiLi's idea  
http://bbs.ctb.pku.edu.cn/putc/f ... &extra=page%3D1

welcome suggestions!


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