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[Challenge Topic] SYNTHETIC CONSORTIA (Laurens Kraal)

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Posted at 2012-4-30 12:17:13 | All floors |Read mode
orginal link: http://www.ucsf-pku.org/index.php/SYNTHETIC_CONSORTIA


Engineering Multicellularity
when can we call someting multicellular?
  • Starting points:
    • mutualistic strains
    • specialized cells
    • only division of some cells (blocking division of others?)
    • connections between cells
      • Zev's stuff?
Goal:
  • Roadmap to engineering multicellularity.
  • What modules do we need?
  • Different approaches to different steps
  • how do you actually go about doing it?
    • order
    • scale (droplet based microfluidics?)
Philosophically:
  • when can we call something multicellular?
  • is it useful for?:
    • studying dev bio
    • biotech

Papers:
  • Ratcliff et al. Experimental evolution of multicellularity. Proceedings of the National Academy of Sciences (2012) vol. 109 (5) pp. 1595-1600
  • Xavier and Foster. Cooperation and conflict in microbial biofilms. Proceedings of the National Academy of Sciences (2007) vol. 104 (3) pp. 876
  • Davidson and Surette. Individuality in bacteria. Annu Rev Genet (2008) vol. 42 pp. 253-268
  • Wintermute and Silver. Emergent cooperation in microbial metabolism. Molecular Systems Biology (2010) vol. 6 () pp. 1-7
  • Brenner et al. Engineering microbial consortia: a new frontier in synthetic biology. TRENDS in Biotechnology (2008) vol. 26 (9) pp. 483-9
  • Weibel. Building communities one bacterium at a time. Proceedings of the National Academy of Sciences (2008) vol. 105 (47) pp. 18075-6
  • Damore and Gore. Understanding microbial cooperation. Journal of Theoretical Biology (2011) pp. 1-11
  • Wintermute and Silver. Dynamics in the mixed microbial concourse. Genes & Development (2010) vol. 24 (23) pp. 2603-2614
  • Dunham. Synthetic ecology: A model system for cooperation. Proceedings of the National Academy of Sciences (2007) vol. 104 (6) pp. 1741
  • Bassler and Losick. Bacterially speaking. Cell (2006) vol. 125 (2) pp. 237-246
给我一块二向箔,清理用

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Posted at 2012-5-11 09:21:44 | All floors
That's great for engineering multicellularity when most people are commit themselves to engineering E. coli or yeast. Well, does a yeast containing a chloroplast mean mutualistic strains? does air spores of mushrooms mean multicellularity? would we use the mutiple-connected air spores to arrange a shape as we want?

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Posted at 2012-5-15 23:12:01 | All floors
Is this topic the same or relevant to the ppt ZhuJunhao presented to us on last Sunday?
some multicellular thing?
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