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[Challenge Topic] Grow size for what?

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Posted at 2012-5-27 15:32:00 | All floors |Read mode
Edited by Leoqi at 2012-5-27 15:51

People keep talking about the limit of cell size a single cell can grow to. However, cell may need different size or size limit for different purpose. Cell size must be connected with cellular function! For example statistically, the size at division is smaller than the size cells can grow to. When growing wild type yeast cells in the rich medium, we can find huge cells under microscopy. These cells are 5 to 10 folders bigger than the average and can live for a duration of several cycles, but they can't divide. Cells of the same genotype also show different size distribution in different environmental condition. Besides, cell size of different species also exhibit quite different ranges. Somebody may give an exact and right answer to  the question of what is the limit of a yeast cell can grow to whether by computing, simulating or even guessing, but the answer is nonsense biologically. I think we should ask why a cell need a certain size to grow for what function. To solve this question, we can do the works listed below. 1) display all the size of different cells of all organisms on the earth to see how big can cell evolve to. one organism represent at lest one niche the cell evolved from, so the biggest cell size on the earth may approach the limit the cell may evolve to. if other organism can grow its cell to that big, why not yeast?
2) find the relationship between the size and the the characteristics of the environment the organism evolved from and the biological functions both the organism and its cell  gained. according to these difference and relationship, we can find out why some cell can't grow big and why some other can, and the increased size is used for what function or purpose.
3) dissect the gained or the lost cellular functions of yeast cells compared with other types of cells of different organisms on the earth, and speculate how big can a single yeast cell grow or why can't it grow that big.

It is just some stupid ideas, any arguments are welcome.

   


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Posted at 2012-5-28 22:51:08 | All floors
comparing to the size range of the whole organism among the earth, the size range of cell is really within a narrow range. In addition, the cell cycle control mechanism, which is tightly related to size control, is extremely conserved from yeast to human.
给我一块二向箔,清理用

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Posted at 2012-5-28 23:35:09 | All floors
Now that the size range of cell is within a narrow range, can we think that the size is a stable steady state?
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