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Joining two issues together: microfluidics and cancer drug resistance

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Posted at 2012-5-28 20:03:24 | All floors |Read mode
Microfluidics, as a rapid developingscience and technology, already offers applications and perspectives in manyfields, especially the pharmaceutical industry. As the challenge topic restrictsits approach to the pervasive disease, it is my opinion that CANCER is actuallythe first choice. Also, it’s such a pity that the challenge topic evolving outof cancer is out of the finally topic list, though cancer drug resistance is alwaysa big issue both in the fundamental research and drug development.
Here I hope that we might focus theapplication of microfluidics on the detection and monitor of drug resistanceduring cancer treatment, thus providing insights into the mechanism andsolutions to this issue.
So dear all who are interested in the topicof microfluidics development, suggestions and arguments are welcomed.

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IP  115.27.133.160

Posted at 2012-5-28 21:47:04 | All floors
Good idea! Many people were interested in the topic evolving out of cancer. Now if the two topics combined, maybe more interesting ideas would be generated.

PS: Recently I read a modeling paper about cancer drug resistance. I can post it here tomorrow.

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Yoh Iwasa, et al. Evolution of resistance during clonal expansion. Genetics 2006 (172): 2557-2566. [url]http://www.genetics.org/content/172/4/2557.short[/url] That's the paper I mentioned yesterday   Posted at 2012-5-29 11:04

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 Author| Posted at 2012-5-28 21:55:15 | All floors
Reply ChangChang Add Thread


    http://thiqaruni.org/pharmacy2/33.pdf
book relating cancer drug resistance by Beverly A. Teicher

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Why I can not open this link?(sad) Is this a e-book?  Posted at 2012-5-29 00:13
Love this idea. Rewarded 20 points~  Posted at 2012-5-28 22:37

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IP  162.105.160.10

Posted at 2012-5-28 22:44:09 | All floors
I love this idea. There is a good review: Lab-on-a-chip: microfluidics in drug discovery (http://www.nature.com/nrd/journal/v5/n3/full/nrd1985.html)

I remember a talk in UCSF about the importance of micro environment in cancer. The speaker mentioned that if one put cancer cell into a "normal " condition where it has 3-D support and appropriate nutrient, its morphology turns back to normal.

One question we should think more is: what's the specific cancer-microfluidic topic we can accomplish in 4 days~

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LiLi, if you can well develop the combination of these two topics, I think it can replace the current topic about microfluidics. Then we can have two topics contributed from the PKzu side.  Posted at 2012-5-28 23:24
给我一块二向箔,清理用

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IP  162.105.103.87

Posted at 2012-5-28 23:47:37 | All floors
When LiLi told me the idea to combine the two topics, I'm very interested in this idea. The microfluidic development need a disease. Obviously, cancer is a suitable disease for this topic. The microfluidics development of cancer drug is really a challenge.

And welcome people who are interested in microfluidics development and evolving out of cancer to join us.

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IP  162.105.103.87

Posted at 2012-5-29 00:11:12 | All floors
Reply zhiyuanli Add Thread


   I have read this paper before. Even I have forgotten this paper.
And it's really a good idea to combine cancer drug and microfluidics. Microfluidics chip is only a way to solve problems, and of course, cancer drug is a worthy task.

And maybe the combination can make more people join this topic~~

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IP  162.105.23.8

Posted at 2012-5-29 11:09:45 | All floors
One related paper:

MM Gottesman. Mechanisms of cancer drug resistance. Annu Rev Med 2002 (53): 615-627.

http://www.ncbi.nlm.nih.gov/pubmed/11818492

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 Author| Posted at 2012-5-30 22:30:32 | All floors
Reply zhiyuanli Add Thread


    Exactly now we have to consider what specific aspects of cancer research should be combined with microfluidics development. My opinion is that we could narrow it down in the cancer drug resistance, maybe the monitoring of mechanism or network of the drug resistance.

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 Author| Posted at 2012-5-30 22:35:51 | All floors
Reply ChangChang Add Thread


    that's quite an excellent conclusion of various kinds of drug resistance, maybe we can try to find out the Achilles' Heel in each pathway~~

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IP  162.105.100.165

Posted at 2012-5-30 23:36:08 | All floors
I'm interested in cancer and I like this idea. We can make best of microfluidics to study cancer.

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IP  162.105.160.41

Posted at 2012-5-31 10:50:59 | All floors
Reply zhiyuanli Add Thread


I've been wondering for a long time what kind of environment is "bad" for cancer cell.
as is known to all, it seems that cancer cell always have higher fitness than non-cancer cells. is there an environment, i mean in vivo, that suits non-cancer cell better than cancer cells? can we verify the existence of such a micro environment & find it, & develop some drugs to change the in vivo micro environment?

in 4 days,  maybe we can find such an environment through some in silico simulation, and design some microfuidic devices for further experiments.
王紫薇

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IP  222.29.46.239

Posted at 2012-5-31 13:18:02 | All floors
Terrific idea! I am very interested in this topic all the time and feel very sorry that the topic was cancelled once!
There are many kinds of cancer therapeutics such as ERBB-directed one. Specifically speaking, we can focus on the resistance of a specific cancer such as breast cancer to a certain kind of therapeutics (eg. trastuzumab is prescribed to some breast cancer patients).
Wow! Looking foward to our next meeting and we can make it in details!

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 Author| Posted at 2012-5-31 20:55:38 | All floors
Reply Amber.Zw.W Add Thread


    I highly appreaciate your idea, microfluidics can provide various microenvironment in a high-throughput manner that can be suitable for screening the worst environment for cancer cells.
    But one more thing to be considered, just as cancer cells can develop drug resistance in time, the harsh environment, which can kill cancer at the monent, may become an evolutionary stress that push cancer cells evolve resistance too.

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 Author| Posted at 2012-5-31 21:50:10 | All floors
Reply YuanYuan Add Thread

Yeah, I am also interested in exploring cancer drug resistance. As drug resistance can appear through different mechanism, such as drug efflux, target alteration.etc, one might have to go through lots of experiments in identifying the specific pathway accounting for a certain drug resistance.  However, each mechanism should has its own molecular marker, all of which we might use microfluidics to detect in parrallel, and monitor the development of all the drug resistance mechanism already known under a specific case.
   

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 Author| Posted at 2012-5-31 22:23:13 | All floors
The biological use of microfluidics can be roughly devided into two parts:
1, on cellular level, cellular microenvironment manipulation, cell sorting, microluidic culture platform;
2, on molecular level, enzyme inhibition study, chemical synthesis and reaction with microreactor, chemical seperation with capillary electrophorisis, DNA manipulaton on chip.

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IP  162.105.11.51

Posted at 2012-6-1 18:23:54 | All floors
Reply LiLi Add Thread


    O(∩_∩)O~When microfluidics "marry" cancer, there are more people talking about this topic now.

   As you say, microfluidics has many advantages, but I think it is really hard to make a worst environment for cancer cell. Because cancer cell is so strong that maybe bad environment can not kill all of them.
I wonder which kind of drug we will choose, because there are many kinds of drugs for cancer (some of them are inefficient) now. And perhaps we will make a microfluidic chips to screen the drugs' effect?~


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microfluidics are often used for high-throughput screen, but drug effects are already tested druring clinic trials before FDA approval~~~maybe screening drug resistance and mechanism will be better~  Posted at 2012-6-6 13:12

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Posted at 2012-6-5 13:23:51 | All floors
cancer cells are living. In evolutionary view, they are mortal, too. Compromise might be better therapy than elimination.

Microfludic screening is a nice idea, and seems applicable.

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It's better for cancer cells to coexist than to kill the person, just as evolution will finally select pathogens with less lethality.  Posted at 2012-6-6 15:51

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 Author| Posted at 2012-6-6 12:54:12 | All floors
Reply songdaidai Add Thread


    http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0010031
http://www.cancerprogress.net/downloads/timelines/progress_in_targeted_cancer_drugs_timeline.pdf

here are papers about the drug development in cancer field, including all the FDA approved drugs and targeted cancer. Maybe we can select our system here.

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Posted at 2012-6-14 01:46:46 | All floors
Micro fluidics seems to be a potential powerful tool for high throughput assays. I am also interested in cancer. I know some studies apply microfluidics to investigate cancer metastasis, such as monitoring cancer cells or detecting chemicals. These are also interesting topics.

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 Author| Posted at 2012-6-16 22:06:06 | All floors
Reply bio.lin Add Thread


    Great~~ Wish you to join us~, please share your ideas with us.
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