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2013.12.3 Computation of Transition State and its Applications in System Biology

Lei Zhang, Ph.D.


Associate Professor

Beijing International Center for Mathematical Research (BICMR), PKU 




13:00pm, Dec. 3, 2013 


Address:Rm. 102, Old Chemistry Building, east Wing, 1rd floor, CQB




The dynamics of complex biological systems is often driven by multiscale, rare but important events. In this talk, I will introduce the numerical methods for computing transition states, and then give two examples in distinct biological systems: one is a multiscale stochastic model to investigate a novel noise attenuation mechanism that relies on more noises in different cellular processes to coordinate cellular decisions during embryonic development; the other is a phase field model to study theneuroblast delamination in Drosophila.


Host:Fangting LI