English  |  BBS  |  Mail  |   中心历  |   会场预定
联系我们

电话:010-62759599

传真:010-62759595

首页 > 10062 > 学术讲座学术讲座

 

北京大学定量生物学中心

学术报告

    目:RNA phase transitions in neurodegenerative diseases

报告人Dr. Ankur JAIN

Damon Runyon Postdoctoral Fellowship Award

The Ronald D. Vale Lab

Department of Cellular and Molecular Pharmacology

University of California San Francisco

    间:1030日(周一)13:00-14:00

    点:北京大学老化学楼东配楼101报告厅

主持人:齐志 研究员

摘 要:

Several neurological and neuromuscular diseases are caused by expansion of short microsatellite repeats. Examples include Huntington disease (CAG expansion), muscular dystrophy (CTG expansion) and some forms of amyotrophic lateral sclerosis (GGGGCC expansion). Two characteristic pathological feature of these diseases are: (1) The RNA transcript with repeats accumulates in the nuclei as aberrant “RNA foci”. (2) RNA foci, as well as disease symptoms, only appear when the number of repeats exceeds a critical threshold. The molecular mechanisms underlying these features were not known. We identified that RNA foci result from sol-to-gel phase transition of the repeat-containing RNA. Phase transitions are mediated by multivalent intermolecular base-pairing between the RNA: increase in the number of repeats corresponds to an increased valency for intermolecular hybridization. Compounds that disrupt base-pairing interactions disrupt RNA foci in patient-derived cells and offer a potential route to therapeutics. Analogous to protein aggregation disorders, we propose that sequence-specific gelation of RNAs could be a contributing factor to neurological disease.

Reference

Jain A and Vale R, “RNA phase transitions in repeat expansion disorders”, Nature546, 243-247 (2017)

News highlights by Nature, Nature Podcast, UCSF News, J Cell Biology, NSMB, Nature, Chemical Biology, Nature Reviews Genetics, Nature Reviews Neurology, ALZ Forum, and Faculty1000

报告人简介:

Dr. Ankur Jain received B.S. in Biotechnology and Biochemical Engineering at Indian Institute of Technology Kharagpur in 2007 and Ph.D. in Biophysics and Computational Biology at University of Illinois at Urbana-Champaign in 2013. Currently he ia post-doctoral scholar in the Department of Cellular and Molecular Pharmacology at University of California San Francisco. His research is focused on phase separation in RNA biology and single-molecule biophysics.