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 北京大学定量生物学中心

学术报告 

     Global background selection: the shaping of genome-wide motif statistics by DNA binding proteins over evolutionary time scales

报告人:Dr. Long Qian

Department of Biology and Center for Genomics and Systems Biology

New York University

    间:19日(周二)13:30-14:30

    点:北京大学老化学楼东配楼101报告厅

主持人:欧阳颀 教授

摘 要:

The composition of a genome with respect to all possible short DNA motifs impacts the ability of DNA binding proteins to locate and bind their target sites. Organisms could benefit from a genome-wide anti-binding landscape that avoid weak, nonfunctional binding to increase the signal-to-noise ratio of molecular recognition, as well as reduce interference between different DNA binding processes. I will talk about the persistent signal of such a process that we identified from genomes of diverse species across domains of life, and the evolutionary model we established to estimate the selective strengths needed to maintain anti-binding landscapes. An example will be given on the avoidance of restriction-modification sites in bacterial genomes as a consequence of noise-induced autoimmunity. I will also talk about the few exceptions we identified in the analysis on eukaryotic transcription factors, where a global pro-binding landscape could prove useful.

报告人简介:

Dr. Long Qian received B.S. in biology at Peking University in 2008 and Ph.D. also in biology at New York University in 2014. Currently she is a post-doctoral scholar with Prof. Edo Kussell (Biology and Physics) at NYU. Her research interests are evolution, theoretical population genetics, genomics, synthetic biology and biophysics.