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    目:Quantitative analysis of energy metabolism报告人Sheng (Tony) Hui, PhD

Lewis-Sigler Institute for Integrative Genomics

Princeton University



主持人汤超 教授

摘 要:

  The primary biochemical activity of an organism is energy metabolism, the constant burning of dietary carbon into CO2. To understand it, I integrate experiments and modeling to quantify fluxes through the energy pathways. In bacteria, I established that E.coli’s choice of energy production pathway is determined by the tradeoff between efficient carbon usage and efficient proteome usage. In mammals, I discovered that the path from glucose to CO2 in mice is through circulating lactate. In future, I will focus on systematic quantification of energy metabolism in mammals, aiming for a holistic understanding of what happens to the food we eat.


  Sheng (Tony) Hui is a postdoctoral research fellow in the lab of Joshua Rabinowitz at the Lewis Sigler Institute for Integrative Genomics of Princeton University. He earned his PhD in Biophysics in 2014 from Terry Hwa’s lab at the University of California, San Diego.