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(Elasticity and shape effects on the cell-nanomaterial interaction)

报告人易新 研究员



    点:北京大学吕志和楼B101报告厅(Rm. B101, Lui Che Woo Building

主持人:宋晨 研究员


摘 要:

While the effects of the size, shape and surface charge of nanoparticles on their biological performances have been extensively investigated, roles of nanoparticle mechanical and geometrical properties in cell interaction remain least explored. In this talk, I will present our theoretical work on the cell interaction with elastic nanoparticles and nanofibers. In particular, I will discuss how particle elasticity and fiber geometry affect the membrane wrapping process and intracellular packing. In the case of membrane wrapping, we found that soft nanoparticles are energetically less prone to full wrapping than stiff ones, but the wrapping of the former is kinetically faster than that of the latter; and the internalization of one-dimensional nanomaterials follows a near-perpendicular entry mode at small membrane tension, but it switches to a near-parallel interaction mode at large membrane tension. In the case of the nanoparticle interaction with a vesicle, we found that soft particles are more energetically prone to full internalization into a vesicle than being released out of the vesicle. For the packing of nanofibers in vesicles, the vesicle morphology and mechanical behaviors are strongly regulated by encapsulated nanofibers of different lengths, finite radii, and elasticity. Corresponding packing phase diagrams are determined. Our results provide valuable insight into the biophysics underlying cell interactions with nanomaterials.



易新博士分别于2005年和2008年在北京大学力学与工程科学系获得学士和硕士学位。2014年毕业于美国布朗大学工学院获得博士学位,期间从事细胞力学和软物质方面的研究。2014-2016年在布朗大学和达特茅斯学院从事博士后研究。2016年加入北京大学工学院力学与工程科学系,任特聘研究员,博士生导师。至今已在国际知名期刊发表SCI文章30余篇,包括Proceedings of the National Academy of Sciences of the U. S. A.Physical Review LettersJournal of the Mechanics and Physics of Solids, Nano Letters等。课题组目前的主要研究方向包括增材制造、细胞力学、软物质力学等。