Demystifying the mystery of bacteria picky eater

Give you an ice cream and a piece of cake. Which one do you eat first? The team of Professor Chao Tang from Peking University found that the bacterial feeding strategy enabled them to optimize their growth. If any strain wants to be willful, eat glucose and lactose, or picky eaters with maltose and malic acid, then the price is a reduction in growth rate and the risk of being eliminated. Combining the topological characteristics of metabolic networks with the optimal allocation of intracellular protein resources, the theoretical model of the research team quantitatively explained the feeding strategies of bacteria against multiple carbon sources.

Demystifying the mystery of bacteria picky eater

Give you an ice cream and a piece of cake. Which one do you eat first? The team of Professor Chao Tang from Peking University found that the bacterial feeding strategy enabled them to optimize their growth. If any strain wants to be willful, eat glucose and lactose, or picky eaters with maltose and malic acid, then the price is a reduction in growth rate and the risk of being eliminated. Combining the topological characteristics of metabolic networks with the optimal allocation of intracellular protein resources, the theoretical model of the research team quantitatively explained the feeding strategies of bacteria against multiple carbon sources.

The study is about the protein inheritance along the cell lineage. In this study, through both computational and experimental approaches, we systematically investigated different factors that affect the inheritance of protein abundance. We derived an an expression for the dependence of protein inheritance on various factors for the first time. Then we traced the yeast cells along the cell lineage for protein abundance by using fluorescence microscopy and microfluidic technology. We found that the influence of different factors on the inheritance of protein varies greatly.

2017 CQB Annual Retreat

2017 CQB Annual Retreat was held on January 22th, 2018, in the Lecture Hall of the College of Chemistry and Molecular Engineering of Peking University. The goal is to promote communication, interaction and cooperation among the research groups. The agenda includes annual report of CQB, 6 invited lectures and 57 presentations by graduate students and postdocs. More than 100 people attended the retreat.


  

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