Dr. Song was invited to give a talk in the Pacifichem 2025 Congress, held in Hawaii in December 2025. He presented our recent work on the Ca²⁺ permeation and selectivity of ryanodine receptors and voltage-gated calcium channels.

Jiaxuan's AMP screening work has been published in Adv. Sci. (Link). This study introduces a mechanism-driven screening approach that leverages machine learning-based computational models to identify antimicrobial peptide sequences capable of targeting bacterial membranes and forming pores. Screening metaproteomes from poison frogs, African clawed frogs, and human skin led to the identification and validation of seven novel peptides. Each exhibited potent antimicrobial activity while demonstrating minimal hemolysis and cytotoxicity. Liposome leakage assays confirmed membrane disruption, with three peptides showing broad-spectrum efficacy against both Gram-positive and Gram-negative bacteria. Single-molecule experiments visualized peptide oligomerization on membranes, and electrophysiological measurements directly verified pore formation by the three broad-spectrum AMPs, suggesting a strong correlation between pore-forming capability and broad-spectrum activity. This research establishes a promising, mechanism-driven strategy for discovering new antimicrobial agents to combat antibiotic resistance. We extend our congratulations to Jiaxuan and all collaborators on this significant publication. Congratulations!

Prof. Chen SONG was invited to deliver a presentation at the 10^th iHuman Forum, convened at ShanghaiTech University from October 31 to November 1, 2025. His talk, entitled "Decoding the Molecular Mechanisms of Valence Selectivity in Ca²⁺ Channels: A Computational Study," addressed key computational insights into ion channel selectivity.

(This photo was taken by Prof. Yuji Sugita)

From October 24th to 26th, 2025, our group participated in the SMART Symposium: 2025 Frontier Symposium in Computational Chemistry, Biophysics, and Biological Sciences held in Shenzhen, China. Prof. Chen SONG and Ruihan were invited to deliver presentations showcasing our group's recent research advancements. We are pleased to announce that Tadsanee received the Poster Award. Congratulations!!

A huge congratulations to Ruihan on winning the National Scholarship! Congratulations!!

Congratulations to Jingze, Lingfeng, and Zefeng on successfully passing their mid-term assessments! This important milestone brings them one step closer to earning their PhD degrees. Well done, and keep up the excellent work!

Ruihan's AMPainter work has been published in Adv. Sci. (Link). AMPainter is a powerful design model for 'painting' the antimicrobial potency on any given peptide sequence, based on the strategy of virtual directed evolution and deep reinforcement learning. The wet lab validations of the designed AMPs were conducted in our lab with Qiushi's participation. Meanwhile, our patents on the model and peptides have been granted recently. Congratulations!

Congratulations to Qiushi and Jun on successfully passing their PhD qualifying exams! They will now continue their research in our group as a formal PhD candidate. Congratulations again！

We are delighted to welcome Qianli and Jiajun to our group, following the successful completion of their rotations. Qianli will focus on MD simulations of the Sec system, and Jiajun will work on predicting protein multiple conformations. Their diverse expertise will be a valuable asset to our group. Welcome!

Dr. Chen Song was invited to deliver a talk at the 8^th National Conference on Statistical Physics and Complex Systems, which was held in Ningbo on July 30, 2025. He presented our recently published work on the Ca²⁺ permeation and selectivity mechanisms of voltage-gated calcium ion channels.