北京大学定量生物学中心

学术报告 

题    目: Membrane potential dynamics reveal magnesium as a determinant of bacterial survival

报告人: Leticia Galera-Laporta, Ph.D.

University of California San Diego (UCSD)

时    间: 9月28日（周一）9:00-10:00

地    点: Online (Zoom会议)

会议 ID：627 9242 4126

https://zoom.com.cn/j/62792424126

主持人: Lucas Carey

摘 要:

Cell-to-cellvariability in stress response is observed even in single-speciesbacterial cultures, with subgroups of cells more resilient to stressthan others. A clear example of this variability is the heterogeneityseen in responses to antibiotic treatments where some bacteria survive,and others die. This higher resilience to antibiotics is generallythought to be associated with “dormant” non-growing cells. I will explain how we discovered an alternative mechanism by measuring membrane potential dynamics of Bacillus subtilis cells, which actively-growing bacteriautilize to cope with ribosome-targeting antibiotics. Our work provides anew perspective on the heterogeneous antibiotic response, emphasizingthe importance of ion flux regulation in bacterial survival.

I will talk about unpublished results, and results from：

1.       D.D. Lee*,L. Galera-Laporta*,M.Bialecka-Fornal*, … J. Garcia-Ojalvo, and G.M. Süel. *equalcontribution. Membrane potential dynamics reveal ion flux modulation as adeterminant of bacterial survival. Cell. 2019

2.       Commentary: A. Du Toit. Unlocking new potentials. Nature Reviews Microbiology (2019)

3.       L. Galera-Laporta and J. Garcia-Ojalvo. Antithetic population response to antibiotics in a polybacterial community. Science Advances. 2020

报告人简介：

LeticiaGalera-Laporta is a postdoctoral researcher at University of CaliforniaSan Diego (UCSD), advised by Prof. Gürol Süel. She received her PhD inBiomedicine at University Pompeu Fabra in 2019, advised by Prof. JordiGarcia-Ojalvo. Leticia uses mathematical modeling and experiments tounderstand how heterogeneity within populations generatescounter-intuitive mechanisms of antibiotic resistance.