发表文章

2026

• Wang H, Zhao F, Li Y, Wang P, Wang Y, Ren P, Li C, Zheng H, Zeng Z*, Pan D*. ZNF296 Drives Immune Evasion in Epithelial Cancers by Repressing Immune Stimulatory Genes. Cancer Research. 2026 Jan 2;86(1):116-130. doi: 10.1158/0008-5472.CAN-25-0153. PMID: 40991281.
  [Abstract][Full Paper]    
• Sun Q, Zhao Y, Qiao S, Wang K, Lu C, Zhang Z, Guo Z, Ding Z, Wang C, Li J, Liu T, Zeng Z*, Liu Z*. Boron neutron capture therapy preserves immune cells and induces robust anti-tumour immunity in preclinical mouse model. Nature Communications. 2026 Jan 8. doi: 10.1038/s41467-025-67984-y. Epub ahead of print. PMID: 41501029.
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2025

• Lu Y, Luo C, Huang L, Wu G, Zhong L, Chu J, Wang F*, Zeng Z*, Pan D*. Functional Genetic Screens Reveal Key Pathways Instructing the Molecular Phenotypes of Tumor-Associated Macrophages.Cancer Immunology Research.2025 Dec 2;13(12):2054-2074. doi: 10.1158/2326-6066.CIR-25-0488. PMID: 40906823.
  [Abstract][Full Paper]    
• Zhao J, Li X, Li X, Ren P, Wu Y, Gong H, Wu L, Huang J, Wang S, Guo Z, Chen M, Zeng Z*, Pan D*. Targeting plasticity in the pyrimidine synthesis pathway potentiates macrophage-mediated phagocytosis in pancreatic cancer models.Journal of Clinical Investigation (JCI).2025 Nov 17;135(22):e193370. doi: 10.1172/JCI193370. PMID: 41243973; PMCID: PMC12618067.
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• Ren P, Zhang R, Wang Y, Zhang P, Luo C, Wang S, Li X, Zhang Z, Zhao Y, He Y, Zhang H, Li Y, Gao Z, Zhang X, Zhao Y, Liu Z, Meng Y*, Zhang Z*, Zeng Z*. Systematic Benchmarking of High-Throughput Subcellular Spatial Transcriptomics Platforms Across Human Tumors.Nature Communications.2025 Oct 17;16(1):9232. doi: 10.1038/s41467-025-64292-3. PMID: 41107232; PMCID: PMC12534522.
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• Tang K, Wu L, Hu Y, Xue T, Jin Y, Zhou X, Luo C, Zhao Y, Tong L, Dai J, Feng D, Zeng Z*, Pan D*.Perturbation of calreticulin potentiates CD8+ T cell-mediated antitumor immunity.Journal of Experimental Medicine (JEM).2025 Oct 6;222(10):e20242360. doi: 10.1084/jem.20242360. Epub 2025 Aug 20. PMID: 4083353.
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• Li Y, Ding Y, Dennis S, Hutch MR, Zhou J, Zhou Y, Li Y, Pillai M, Ghotbaldini S, Garcia MA, Broad MS, Mao C, Dulai PS, Cheng F, Zeng Z*, Luo Y*.SOAR elucidates biological insights and empowers drug discovery through spatial transcriptomics.Science Advances.2025 Jun 13;11(24):eadt7450.doi: 10.1126/sciadv.adt7450.Epub 2025 Jun 11.PMID: 40498826.
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• Zhan X,Liu Y,Guo Y,Zhou W,Yan Y,Zeng H,Dong X,Chen X,Ma R,Liu Z,Zhu F,Zheng X,Li X,Yin J,Chan FK,Liu C,Liu L,Xu X,Hou Y,Tao H,Dong Y,Zeng T,Li Y*,Zhou J*,Zeng Z*,Feng Y*.Single cell resolved spatial immune repertoire unveils spatial heterogeneity of lymphoid aggregates in human immune disorders.bioRxiv.2025.01.16.630222.
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• Luo C, Zhang R, Guo R, Wu L, Xue T, He Y, Jin Y, Zhao Y, Zhang Z, Zhang P, Ye S, Li X, Li D, Zhang W, Wang C, Lai L, Pan-Hammarström Q, Wucherpfennig K, Gao Z*, Pan D*, Zeng Z*.Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells. Immunity. 2025 Mar 11;58(3):745-765.e9. doi: 10.1016/j.immuni.2025.02.007. Epub 2025 Feb 28. PMID: 40023158.
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• Zhou X, Xu T, Li C, He Y, Hu Y, Gong H, Li J, Jiang H, Wen L, Fu Y, Zeng Z*, Pan D*. Potentiating anti-tumor immunity by re-engaging immune synapse molecules.Cell Reports Medicine. 2025 Feb 14:101975. doi: 10.1016/j.xcrm.2025.101975.Epub 2025 Feb 24. PMID: 39999838.
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2023

• Wu L, Jin Y, Zhao X, Tang K, Zhao Y, Tong L, Yu X, Xiong K, Luo C, Zhu J, Wang F, Zeng Z*, Pan D*. Tumor aerobic glycolysis confers immune evasion through modulating sensitivity to T cell-mediated bystander killing via TNF-α. Cell Metabolism. 2023 Sep 5;35(9):1580-1596.e9. doi: 10.1016/j.cmet.2023.07.001. Epub 2023 Jul 27. PMID: 37506695.
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2022

• Zeng Z#, Gu S#, Wong C, Li D, Lin Y, Wong C, Ouardaoui N, Zhang W, Brown M, Liu XS*: Machine learning on syngeneic mouse tumor profiles to model clinical immunotherapy response. Science Advances (2022) 10.1126.
  [Abstract][Full Paper]
• Zeng Z#, Gu S#, Yang L, Wong C, Ouardaoui N, Zhang W, Li D, Weirather J, Zhang Y, Meyer C, Rodig S, Hodi SF*, Brown M*, Liu XS*: Hippo signaling pathway regulates cancer cell-intrinsic MHC-II expression. Cancer Immunology Research (2022) 10.1158.
  [Abstract][Full Paper]    
• Zeng Z#, Li Y#, Li Yi#, Luo Y*. Statistical and machine learning methods for spatially resolved transcriptomics data analysis. Genome Biology. 2022. 10.02653
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• Zhou L#, Zeng Z#, Egloff AM, Guo F, Campbell KM*, Du P, Fu J, Zolkind P, Ma X, Zhang Z, Zhang Y, Wang X, Gu S, Riley R, Nakahori Y, Keegan J, Haddad R*, Schoenfeld JD, Griffith O, Manguso RT, Lederer JA, Liu XS, Uppaluri R*. Checkpoint blockade-induced CD+ Tcell differentiation in head and neck cancer responders. J Immunother Cancer (JITC). 2022. 10(1), e004034.
  [Abstract][Full Paper]
• Zeng Z#*, Wong C#, Yang L#, Ouardaoui N, Li D, Zhang W, Gu SS, Zhang Y, Liu Y, Wang Z, Fu J, Zhou L, Zhang B, Kim S, Yates KB, Brown M, Freeman GJ, Uppaluri R, Manguso, Liu XS*. 2021. TISMO: syngeneic mouse tumor database to model tumor immunity and immunotherapy response.Nucleic Acids Research. 2022 Jan 7;50(D1):D1391-7.
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2021

• Kumar S#, Zeng Z#, Bagati A, Tay RE, Sanz LA, Hartono SR, Ito Y, Abderazzaq F, Hatchi E, Jiang P, Cartwright ANR, Olawoyin O, Mathewson ND, Pyrdol JW, Li MZ, Doench JG, Booker MA, Tolstorukov MY, Elledge SJ, Chedin F, Liu XS*, Wucherpfennig KW*. CARM1 inhibition enables immunotherapy of resistant tumors by dual action on tumor cells and T cells. Cancer Discovery. 2021. 11:2051-71.
  [Abstract][Full Paper]
• Zeng Z#, Fu J#, Cibulskis C, Jhivari A, Gumbs C, Das B, Sanchez-Espiridion B, Janssens S, Taing L … Meerzaman D, Thurin M, Futreal PA, Karlovich C, Gabriel SB, Wistuba II, Liu XS*, Wu C. 2020. Cross-site concordance evaluation of tumor DNA and RNA sequencing platforms for the CIMAC-CIDC network. Clinical Cancer Research. Epub ahead of print.
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