Congrats to Song

Congratulations to Song YANG, who has passed his qualifying exam! Song is working on a mechanosensitive ion channel and has found something surprising …

Dr. Zhenli XU visited us


Invited by Dr. Chen SONG, Dr. Zhenli XU from Shanghai Jiao Tong University visited us and presented his exciting work on the random batch Ewald method and improved Poisson-Nernst-Planck (PNP) method for computational studies of charged systems. We had fruitful discussions, and we look forward to extensive collaborations with Dr. XU’s group!


Yanyan and Yang left

Yanyan and Yang have finished their postdoc training in the group and moved on to their new and more independent positions. Both of them have done well in the last several years. Yanyan was a semi-independent member of the group, supported by the Boya Fellowship, and she has learned extensive modeling and simulation techniques. Yang has also made progress in every aspect of his research. We wish them all the best in their future career development.

Yanyan’s Plexin paper online

Yanyan has been trying to understand the antithetic effect of homologous RND1 and RhoD GTPases in mammalian plexin regulation using MD simulations and proposed a putative structural model. This work is now published on eLife, which is a perfect ending of Yanyan’s postdoc training in the group, co-supervised by Drs Yibing SHAN and Chen SONG. This work was in collaboration with Dr. Xuewu ZHANG’s lab at UT Southwestern Medical Center. The paper can be found here.

Yang’s NompC paper online

In collaboration with Prof. Zhiqiang YAN’s lab, we studied the gating mechanism of the tethered mechanosensitive ion channel NompC by using MD simulations and electrophysiology experiments. We revealed the molecular details of an interesting “push-to-open” gating mechanism for this unique channel, which may enable cells to sense compression or shrinkage. Congratulations to Yang and many thanks to everyone who participated in the project. The paper is now online at: https://elifesciences.org/articles/58388

Seminar from Prof. Shi-Jie CHEN

Chen SONG and Chun TANG invited Prof. Shi-Jie CHEN from the University of Missouri to talk about his work on the prediction of RNA structures and small molecule-RNA interactions in the CQB Seminar on May 17. It was a popular seminar, with more than 90 people attended the online Zoom Meeting and many interesting questions discussed.

Chunhong’s RyR Paper Online

Chunhonginvestigated the valence selectivity of RyR channels by using atomistic MD simulations, and observed the details of competition between Ca++ and K+ in the extended selectivity filter of RyRs. The presence of Ca++ significantly decreases the K+ conductance, while K+ has little impact on Ca++ permeation, due to the much stronger binding of Ca++ in the highly negatively charged and size-limited luminal vestibule. This is a further application of our recently developed multisite Ca++ model, showing atomistic details of valence selectivity of RyRs that are in good agreement with previous experimental findings and simplified models. The paper can be found here.

GBA Biophysics Forum


Dr. Chen SONG was invited to give a talk at “The First Great Bay Area Biophysics and New Drug Discovery Forum” on April 10, where he presented our recent story on the valence selectivity of ryanodine receptors. Dr. Yang WANG presented a poster of our NompC work at the forum, which attracted much attention.