Jingze Duan's first paper focusing on NOMPC has been published online in eLife (Link). NOMPC, a mechanosensitive ion channel from the TRP family, converts mechanical stimuli into ionic signals to excite neurons. Using all-atom molecular dynamics simulations, we identified that torque on the TRP domain toward the extracellular side directly drives channel opening, with compression and twisting of the AR domain coupling to facilitate this process. These findings support a twist-to-open gating model mediated by the AR domain's compression-twist coupling. Congratulations!