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Center of Quantitative Biology Academy for Advanced Interdisciplinary Studies Peking University Beijing, China E-mail: zhiqi7@pku.edu.cn Web: http://cqb.pku.edu.cn/qizhi/ |
Education and Training:
2006 – 2013: University of Illinois at Urbana-Champaign, IL, USA, Ph.D., Biophysics
2002 – 2006: Purdue University, IN, USA, M.S., Physics
1999 – 2002: Peking University, Beijing, China, M.S., Physics
1995 – 1999: Beijing University of Science and Technology, Beijing, China, B.S., Applied Physics
Research interests:
The ultimate research goal in my laboratory is developing next-generation single-molecule biophysical technologies, and combining these new methods with non-equilibrium biophysical models to explore in-depth mechanistic details in the molecular biology field, particularly in transcription control and DNA repair.
Academic experiences:
2016 – present: Assistant Professor, Center of Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China
2016 – 2021: Principal Investigator, Peking-Tsinghua Center of Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China
2013 – 2016: Postdoc Research Scientist, Columbia University, NY, USA
Honors And Awards:
2023 Boya Distinguished Professor, Peking University
2022 The National Science Fund for Distinguished Young Scholars
2021 Teaching Award, Peking University
2019 Teaching Excellence Award, Peking University
2018 Peking University Boya Young Fellow
2017 The National Science Fund for Young Scholars (Oversea)
2011 Lebus Graduate Scholar Award, University of Illinois at Urbana-Champaign, USA
2001 'May the Fourth' Fellowship, Peking University
2000 'May the Fourth' Fellowship, Peking University
Selected publications:
PKU publications (*co-first author; # co-corresponding author)
5. Ding, J.*, Li, X.*, Shen, J.*, Zhao, Y., Zhong, S., Lai, L., Niu, H.#, and Qi, Z.# (2023). ssDNA accessibility of Rad51 is regulated by orchestrating multiple RPA dynamics. Nature Communications 14, 3864.
4. Zhou, R., Tian, K., Huang, J., Duan, W., Fu, H., et al., Qi, Z.#, Ji. X.# (2022). CTCF DNA-binding domain undergoes dynamic and selective protein–protein interactions. iScience 25, 105011.
3. Shen, J.*, Zhao, Y.*, Pham, N.T.*, Li, Y., Zhang, Y., Trinidad, J., Ira, G., Qi, Z.#, and Niu, H.# (2022). Deciphering the mechanism of processive ssDNA digestion by the Dna2-RPA ensemble. Nature Communications 13, 359.
2. Zuo, L., Zhang, G., Massett, M., Cheng, J., Guo, Z., Wang, L., Gao, Y., Li, R., Huang, X.#, Li, P.#, Qi, Z.# (2021). Loci-specific phase separation of FET fusion oncoproteins promotes gene transcription. Nature Communications 12, 1491.
The editors at Nature Communications have put together an Editors’ Highlights webpage of recent research called “From molecules and cells to organisms” and our paper was chosen to be featured (www.nature.com/collections/bbcaeejggj). The editors at Nature Communications have put together an Editors’ Highlights webpage of recent research called “Protein Liquid-Liquid Phase Separation in diseases” and our paper was chosen to be featured (www.nature.com/collections/bbaiabggbh).
1. Zhou, H., Song, Z., Zhong, S., Zuo, L., Qi, Z.#, Qu, L.-J.#, and Lai, L.# (2019). Mechanism of DNA-Induced Phase Separation for Transcriptional Repressor VRN1. Angewandte Chemie (International ed in English) 58, 4858-4862.
PKU Scientific Research Highlights 2019
Prior to PKU (*co-first author; +co-second author; # co-corresponding author)
3. Lee, J.Y., Terakawa, T.*, Qi, Z.*, Steinfeld, J.B., Redding, S., Kwon, Y.H., Gains, W.A., Zhao, W.X., Sung, P., and Greene, E.C. (2015). Base triplet stepping during DNA strand exchange by the Rad51/RecA family of recombinases. Science 349 (6251), 977-981.
2. Qi, Z., Redding, S., Lee, J.Y., Gibb, B., Kwon, Y., Niu, H.Y., Gaines, W.A., Sung, P., and Greene, E.C. (2015). DNA Sequence Alignment by Microhomology Sampling during Homologous Recombination. Cell 160, 856-869.
1. Qi, Z., Pugh, R.A., Spies, M., and Chemla, Y.R. (2013). Sequence-dependent base pair stepping dynamics in XPD helicase unwinding. Elife 2.
Professional activities:
2021-now: Deputy secretary-general of the Chinese Biophysical Society’s Monomolecular Biology Academic Subgroup
2019-now: Director of the Chinese Biophysical Society’s Academic Subgroup of Phase Transition and Phase Separation of Biological Macromolecules
2019-now: Faculty Member in the Molecular Biological Physics Section in Faculty Opinions (https://facultyopinions.com)
