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jfpei@pku.edu.cn Center for Theoretical Biology, Academy for Advanced Interdisciplinary Studies, Peking University |
Education:
1998-2002, Ph.D., Institute of Process Engineering, Chinese Academy of Sciences, Chemical Engineering
1995-1998, M.S., Wuhan Institute of Virology, Chinese Academy of Sciences, Microbiology
1991-1995, B.S., Wuhan University, Biology
Research interests:
Molecular Docking, De Novo Drug Design, Systems-Based Drug Design, Multi-target Drug Design, Lead Optimization, Drug Design Applications.
Academic Work experiences:
2006-now, Associate Professor, Academy of Advanced Interdisciplinary Studies, Peking University
2002-2006, Post Doc., Department of Chemistry, Department of Physics, Peking University
2005-2006, Short-Term Visiting Scholar, SUNY Buffalo
Selected publications:
1. Long, H.; Zhang, L.; Lv, M.; Wen, Z.; Zhang, W.; Chen,W.; Zhang, P.; Li, T.; Chang, L.; Jin, C.; Wu, G.; Wang, X.;Yang, F.; Pei, J.; Chen,P.; Margueron R.; Deng H.; Zhu, M.*; Li, G.*, H2A.Z Facilitates Licensing and Activation of Early Replication Origins, Nature, 2020,doi:10.1038/s41586-019-1877-9.
2. Liu, J.; Pei, J.*; Lai, L.*, A combined computational and experimental strategy identifies mutations conferring resistance to drugs targeting the BCR-ABL fusion protein. Communicatios Biology, Accepted.
3. Xu, Y.; Lin, K.; Wang, S.; Wang, L.; Cai, C.; Song, C.; Lai, L.; Pei, J.*, Deep learning for molecular generation. Future Medicinal Chemistry, 2019, 11: 567-597.
4. Xu, Y.; Wang, S.; Hu, Q.; Gao, S.; Ma, X.; Zhang, W.; Shen, Y.; Chen, F.; Lai, L.*; Pei, J.*, CavityPlus: a web server for protein cavity detection with pharmacophore modelling, allosteric site identification and covalent ligand binding ability prediction. Nucleic Acids Research, 2018, W374–W379.
5．li, X.; Xu, Y.; Lai L.; Pei, J.*, Prediction of human cytochrome P450 inhibition using a multi-task deep autoencoder neural network . Molecular Pharmaceutics, 2018, 15, 4336–4345
6.Wang, X., Shen, Y.; Wang, S.; Li, S.; Zhang, W., Liu, X.; Lai, L.; Pei, J.*; Li, H.;*, PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database. Nucleic Acids Research, 2017, 45, W356–W360.
7．Sun, T.; Zhou, B.; Lai, L.; Pei, J.*, Prediction of PPI using a deep-learning algorithm. BMC Bioinformatics, 2017, 18: 277.
8．Zhao, L.; Sun, T.; Pei, J.*; Ouyang, Q.*, Mutation-induced protein interaction kinetics changes affect apoptotic network dynamic properties and facilitate oncogenesis. Proceedings of the National Academy of Sciences of the United States of America, 2015, 112, E4046-E4054.
9．Xu, Y.; Dai, Z.; Chen, F.; Gao, S.; Pei, J.*; Lai, L.*, Deep learning for drug-induced liver injury. Journal of Chemical Information and Modeling, 2015, 55, 2085-2093.
10．Pei, J., Yin, N., Ma, X., and Lai, L.*, Systems biology brings new dimensions for structure-based drug design. Journal of the American Chemical Society, 2014, 136, 11556–11565.
