Research interests:

Our research focus is on protein-ligand interaction. 
We base on three-dimensional structure of the proteins or biologic network to design, synthesize and bioassay the potential drugs. We synthesize novel organic molecules as probes to modulate the biosystem.

Academic  Work experiences:

Associate Professor, College of Chemistry and Molecular Engineering, Peking University，Member of Center for Theoretical Biology, Peking University.
Postdoctor,1999.7-2001.10, Peking University. 
Visiting Fellow, 2004.9-2005.2, Free University of Berlin, Germany.
DFG visiting Fellow, 2006.7-9, Free University of Berlin, Germany.

Selected publications:

1.  Xiaobing Deng,Xiaoling Zhang, Bo Tang,Hongbo Liu, Qi Shen, Ying Liu*, Luhua Lai*. Design, Synthesis, and Evaluation of Dihydrobenzo[cd]indole-6-sulfonamide as TNF-α Inhibitors. Front. Chem.,2018,6,98.

2.   Taikangxiang Yun, Tan Qin, Ying Liu*, Luhua Lai*. Identification of acylthiourea derivatives as potent Plk1 PBD inhibitors. Eur. J. Med. Chem. 2016,124:229-236.

3.   Taikangxiang Yun, Tan Qin, Ying Liu*, Luhua Lai*. Discovery of Non-ATP-Competitive Inhibitors of Polo-like Kinase 1. ChemMedChem 2016, 11(7): 713-717.

4.   Hu Meng, Ying Liu*, Luhua Lai*.Diverse Ways of Perturbing the Human Arachidonic Acid Metabolic Network To Control Inflammation. Acc. Chem. Res. 2015, 48 (8):2242–2250.

5.    Erchang Shang, Yaxia Yuan, Xinyi Chen, Ying Liu*, Jianfeng Pei*, and Luhua Lai*.De Novo Design of Multitarget Ligands with an Iterative Fragment-Growing Strategy. J. Chem. Inf. Model., 2014, 54 (4):1235–1241.

Other Activities:

1. Lu-hua Lai, Ying Liu, Zhen-ming Liu, Ke-qiang Fan, Chang-kang Huang, Ping Wei, Jian-feng Pei, Shi-yong Liu, Hao Chen. Non-peptidic Inhibitors of SARS coronavirus 3C-like proteinase and their applications. Chinese Patent. Serial No. ZL 200510086932.3.
2. Ying Liu, Lu-hua Lai, Ya-bing Feng, Lei Jia. An improved synthesis of a kind of phospholipase A2 inhibitors. Chinese Patent. Serial No. ZL 02153407.1.