北京大学定量生物学中心

学术报告

题目: Sequence-Dependent Dynamics, Membrane Association, and Drug Binding of Intrinsically Disordered Proteins

报告人: Professor Huan-Xiang Zhou

Department of Chemistry and Department of Physics, University of Illinois Chicago

时间: 11月03日（周一）13:00-14:00

地点: 吕志和楼B101

主持人: 唐淳 教授

摘要:

Intrinsically disordered proteins (IDPs) account for a significant fraction of any proteome and are central to numerous cellular functions. Yet how sequences of IDPs code for their conformational ensembles, conformational dynamics, and ultimately, functions is poorly understood. I will present advances in three areas using molecular dynamics simulations complemented by NMR spectroscopy. First, we have identified local interactions and residual secondary structure as major determinants of backbone dynamics and, based on this understanding, developed a predictor, SeqDYN, for backbone amide transverse relaxation rates. Second, we have elucidated a myriad of activities mediated by membrane association, including membrane anchoring of the Z-ring for bacterial cell division and facilitation of microtubule binding, as well as membrane-assisted aggregation. Lastly, we have demonstrated that residue-specific drug binding propensities of IDPs can be predicted from sequences.

报告人简介：

Professor Huan-Xiang Zhou is the LAS Endowed Chair in Natural Sciences at UIC since 2017. He is a Fellow of the Biophysical Society (2023), American Physical Society (2010), and AAAS (2008). His research group focuses on theoretical, computational, and experimental studies in molecular and cellular biophysics.