博士 Doctor (已毕业)
邮箱 / Mail Address:xuegang19 at pku.edu.cn
所在单位 / Current Affiliation:北京大学前沿交叉学科研究院
专业 / major:整合生命科学(物理学)
研究关键词 / Research Keywords:
cell fate decisions, gene regulatory network, logic gates
研究概述 / Research Overview:
细胞命运决定以及基因调控网络
Cell Fate Decisions and Gene Regulatory Network
研究介绍 / Research Introduction:
The decoding of cell fate decisions mechanisms and kinetic properties is one of the outstanding problems in developmental biology, and whether cell fate is executed precisely and unambiguously is relevant to various diseases. Cell fate is implemented by a core network of transcription factors. Now we explore the dynamics of cell fate decisions including stem cell differentiation, cell reprogramming via constructing gene regulatory network (GRN) models, and anticipate to further apply dynamical models in oncogenesis, cancer metastasis, precision medicine and so forth.