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lhlai_at_pku.edu.cn Website:http://mdl.ipc.pku.edu.cn
Education: B.Sc., 1984, Peking University; M.Sc., 1987, Peking University; Ph.D., 1989, Peking University. 1998-1999, Berkeley Scholar, University of California at Berkeley. |
Research interests:
(1) Protein sequence and structure relationship and de novo protein design;
(2) Protein interactions and biomolecular recognition mechanism, functional protein design;
(3) Structural based and systems based drug design
Academic Work experiences:
1989-1990, Lecturer,
1990-1992, Associate Professor in Department of Chemistry, Peking University;
1992-, Professor, College of Chemistry and Molecular Engineering, Peking University;
2001-Cheung Kong Professor, College of Chemistry and Molecular Engineering, Peking University;
2000- Deputy Director, Center for Theoretical Biology, Peking University.
Selected publications:
1. Liang, H. H.; Chen, H.; Fan, K. Q.; Wei, P.; Guo, X. R.; Jin, C. W.; Zeng, C.; Tang, C.; Lai, L. H.*, De Novo Design of a beta alpha beta Motif. Angew. Chem. Int. Ed. 2009, 48, (18), 3301-3303.
2. Yang, K., Bai, H. J., Ouyang，Q., Lai, L. H.*, Tang, C., Finding multiple target optimal intervention in disease-related molecular network. Mol. Syst. Biol. 2008, 4:228.
3. Wei， D. G.§, Jiang, X. L.§, Zhou, L., Chen, J., He, C., Yang, K., Liu, Y., Pei, J. F., Lai, L. H.*,. Identifying multi-target inhibitors by combining molecular docking with common pharmacophore matching. J. Med. Chem. 2008, 51 (12), 3360 - 3366.
4. Liu S§, Liu SY§, Zhu XL, Liang HH, Cao AN, Chang ZJ and Lai LH*. Nonnatural protein-protein interaction-pair design by key residues grafting. Proc Natl Acad Sci USA 2007, 104:5330-5335.
5. Yang K, Ma WZ, Liang HH, Ouyang Q, Tang C and Lai LH*. Dynamic simulations on the Arachidonic Acid Metabolic Network. PLoS Compt. Biol., 2007, 3:523-530.
6. Zhang, Z. Q.; Chen, H.; Lai, L. H.*, Identification of amyloid fibril-forming segments based on structure and residue-based statistical potential. Bioinformatics 2007, 23, (17), 2218-2225.
7. Chen, H.; Wei, P.; Huang, C. K.; Tan, L.; Liu, Y.; Lai, L. H.*, Only one protomer is active in the dimer of SARS 3C-like proteinase. J. Biol. Chem. 2006, 281, (20), 13894-13898.
Other activities:
PLoS Comp. Biol. Associate editor;
BMC Bioinoformatics, editorial board member.
Group Members:
