北京大学定量生物学中心

学术报告 

题    目:  What is aging and when does aging start?

报告人: Meng-Qiu Dong

National Institute of Biological Sciences, Beijing, and Tsinghua Institute of Multidisciplinary Biomedical Research

时    间: 4月19日（周一）13:00-14:00

地    点: 北京大学老化学楼东配楼101报告厅

主持人: 林一瀚 研究员

摘 要:

Aging is a subject where the theorists have found no consensus, and where every existing theory is challenged by some experimental finding that contradicts it. Historically, this has been the hallmark of a field ripe for new insights, often with ramifications that ripple through science. Using C. elegans as a model system, we address a fundamental question “what is aging?” My lab has taken an approach that starts with characterizing the aging process in a systematic and quantitative manner. This includes quantifying abundance changes of mRNAs, proteins, and metabolites on a global scale. By documenting the age-associated molecular changes in C. elegans, we aim to find the earliest sign of aging and the biomarkers of physiological age. I will discuss the results we have obtained and potential insights that could be gained from them.

报告人简介：

董梦秋，北京生命科学研究所高级研究员。分别在四川大学、中国科学院上海生物化学研究所和美国耶鲁大学获得学士、硕士和博士学位。2001-2007年先后在美国加州大学圣迭戈分校和斯克利普斯研究院进行博士后研究。 2007年11月回国，带领课题组以线虫为模型研究关于衰老的基础生物学问题，同时开发基于质谱的蛋白质组学技术。实验室在两个领域都取得了突破性进展，相关文章发表在Nature、Nature Methods、eLife、Journal of Proteome Research、Analytical Chemistry等期刊。目前实验室衰老研究的重点是解析线虫衰老的生物学过程，试图回答衰老是什么、何时开始、是否由遗传程序控制等基本问题。