北京大学定量生物学中心

学术报告 

题    目：Nonequilibrium Thermodynamics of Biochemical Oscillators: Phase Accuracy, Entrainablity, and Synchronization

报告人：Prof. Yuhai Tu

IBM T. J. Watson Research Center

Center for Quantitative Biology, Peking University

时    间：11月4日（周一）13:00-14:00

地    点：北京大学吕志和楼B101报告厅

主持人：来鲁华 教授

摘 要:

A central problem in systems biology is how living systems manage to perform precise functions (development, replication, signaling, etc.) by using inherently noisy biochemical networks. What are the molecular mechanisms for control? What are the design principles for the underlying biochemical networks? What are the energy costs for regulation? In this talk, we will present some of our recent work in addressing these general questions in the context of biochemical oscillators from a nonequilibrium thermodynamics perspective. We will first briefly describe two published work on the molecular mechanism and energy cost for enhancing phase accuracy of biochemical oscillators [1], and the design principles for oscillatory biochemical networks to achieve both high entrainability and low phase fluctuations [2]. We will then focus on discussing our most recent work on the nonequilibrium thermodynamics of synchronization of coupled molecular clocks [3].

[1] “The free-energy cost of accurate biochemical oscillations”, Y. Cao, H. Wang, Q.  Ouyang, and Yuhai Tu, Nature Physics, 11, 772, 2015.

[2] “Design principles for enhancing phase sensitivity and suppressing phase fluctuations simultaneously in biochemical oscillatory systems”, C. Fei, Y. Cao, Q. Ouyang, and Yuhai Tu, Nature Communications, doi:10.1038/s41467-018-03826-4, 2018.

[3] “Nonequilibrium thermodynamics of coupled molecular oscillators: \\ The energy cost and optimal design for synchronization”, Dongliang Zhang, Y. Cao, Q. Ouyang, and Yuhai Tu, to appear in Nature Physics, 2019.

报告人简介：

涂豫海教授为美国IBM T. J. Watson Research Center 理论与计算物理实验室主任，北京大学定量生物学中心成员。他1983年进入中国科技大学少年班学习，1987年通过CUSPEA考试进入美国加州大学圣地亚哥分校物理系读研究生，1991年获得物理学博士学位。获得博士学位后，成为美国加州理工学院部门奖研究员。 1994 年加入著名的 IBM T. J. Watson 研究中心做研究科学家，从 2002 年起任该中心理论与计算物理实验室主任。涂豫海博士在 36 岁时由于在统计物理理论及计算生物学中的创新性应用方面的杰出贡献被当选为美国物理学会会士（ APS Fellow ），现研究方向和兴趣为非平衡统计物理，非线性动力学，表面物理和计算生物学。