北京大学定量生物学中心

学术报告

题 目: Mechano-morphogenesis and Self-organization in Bacterial Biofilms

报告人: 张秋婷 博士

副教授，北京航空航天大学机械工程及自动化学院

时 间: 3月18日（周一）13:00-14:00

地 点: 吕志和楼B101

主持人: 林杰 研究员

摘 要:

Biofilms are surface-associated bacterial communities embedded in an extracellular matrix. Bacterial biofilms can cause chronic infections and they clog pipes and filters in industry. In many conditions, biofilms grow inside a structured, confined environment. However, despite the importance of the bacteria-environment interaction, little is known as to how mechanical confinement interferes with the biofilm developmental program and how the proliferation of biofilm cells, in turn, deforms or even damages the surrounding environments as feedback to control the biofilm growth. In this presentation, using Vibrio cholerae as a model biofilm former, we reveal the biophysical and biomechanical principles underlying biofilm formation, from a soft matter perspective. We present technique to image living, growing bacterial biofilms from single founder cells to ten thousand cells at single-cell resolution. Moving to more medically relevant environments, we investigate the mechanical feedback between biofilm growth and environmental deformation, at both the continuum level and single-cell level.

报告人简介：

张秋婷，北京航空航天大学机械工程及自动化学院副教授，博士生导师，国家级青年人才。2019年博士毕业于美国天普大学，后于2019-2022年在美国耶鲁大学从事博士后研究员工作。主要研究方向包括生物活性软物质物理与力学、多功能微纳仿生表面的结构设计与制造、智能超材料、软体机器人等。在PNAS、Nat. Phys.、JMPS、Nat. Commun.、Adv. Funct. Mater.等期刊发表SCI论文20余篇。