北京大学定量生物学中心

学术报告

题 目： Simple Models of Evolution and Population Dynamics of Bacterial Strains: Kill-the-Winner, Kill-the-Loser, and Kill-the-King

报告人： Prof. Sergei Maslov

 Departments of Bioengineering and Physics, Carl R. Woese Institute for Genomic Biology, National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign

时 间： 2017年2月13日13:00-14:00

地 点： 北京大学老化学楼东配楼101报告厅

主持人：汤超 教授

摘要：

I will present two simple "bottom down" models we recently proposed and studied. The first model describes the evolutionary dynamics of bacterial genomes subject to mutations and horizontal gene transfer followed by homologous recombination [1,2]. It quantifies the role of recombination on population coherence and speciation in bacteria. The computational methods developed as a part of this model allow one to make sense of large collections of genomes of individual bacterial strains. The other model [3,4] describes the population dynamics in ecosystems exposed to episodic collapses. This happens e.g. in a mixed population of bacterial strains periodically decimated by phages following Kill-the-Winner strategy or its variants.

参考文献：

[1] Dixit PD, Pang TY, Studier FW, Maslov S. (2015) Recombinant transfer in the basic genome of Escherichia coli. Proc Natl Acad Sci USA. 112(29):9070-5.

[2] Dixit PD, Pang TY, Maslov S. (2016) Recombination-driven genome evolution, population structure, and stability of bacterial species, (Genetics under review) bioRxiv 067942; http://dx.doi.org/10.1101/067942.

[3] Maslov S, Sneppen K (2015) Diversity waves in collapse-driven population dynamics, PLoS Comput Biol 11: e1004440.

[4] Maslov S, Sneppen K (2017) Population cycles and species diversity in dynamic Kill-the-Winner model of microbial ecosystems (bioRxiv (2016) http://dx.doi.org/10.1101/067124) Scientific Reports 7, 39642, doi: 10.1038/srep39642

报告人简介：

Sergei Maslov is a Full Professor of Bioengineering and Bliss Faculty Scholar at the University of Illinois Urbana-Champaign with appointments at the Department of Bioengineering, Carl R. Woese Institute for Genomic Biology, National Center for Supercomputing Applications, and Physics Department. He also holds a joint appointment at Argonne National Laboratory near Chicago. He works on computational modeling in evolutionary and systems biology, dynamics of microbial ecosystems and complex networks in biological, technological, and social systems. Dr. Maslov is a recipient of the Presidential Early Career Award for Scientists and Engineers where he was recognized "for his contribution to the physics of complex systems".