北京大学定量生物学中心

学术报告

题 目： Motorcycle First, Automobile Later — Yeast Models, Human Interests

报告人： Prof. Zhaohua Tang

Keck Science Department, Claremont McKenna College, Pitzer College, and Scripps College, Claremont, CA

时 间： 2017年2月27日13：00-14：00

地 点： 北京大学老化学楼东配楼101报告厅

主持人： 来鲁华 教授

摘要：

To understand how an internal combustion engine works, we may initially dissect a motorcycle rather than a Mercedes.To understand fundamental mechanisms of cell cycle and gene expression in eukaryotes, there are advantageous to employ yeasts as model organisms to address questions of human interests.Two ongoing projects will be presented as examples.In the first project, using two divergent yeasts： fission yeast and budding yeast, we seek to develop a global picture of the mechanisms for cellular response to phenol derivatives, BPA, BHA, and BHT, which are widely present in daily life as environmental pollutants.We are investigating in an evolutionary context whether the two yeasts handle the environmental challenge in the same way or different ways, that is, using similar pathways and corresponding gene elements or not.In the second project, we explore novel roles of two protein kinases, Dsk1 and Kic1, which are involved in the interplay between cell cycle regulation and multiple steps of eukaryotic gene expression in fission yeast.The two kinases are members of LAMMER-related kinases that are conserved through evolution and play important roles in cell growth, differentiation, hepatitis B virus infection, cancer development and sensitivity to anti-cancer drugs, insulin-regulated glucose metabolism and nutrient homeostasis.

报告人简介：

Zhaohua Tang, Ph.D., Professor of Biology

W. M. Keck Science Department (Keck Science)

Claremont McKenna, Pitzer, and Scripps Colleges

925 North Mills Avenue, Claremont, CA 9171, USA

EDUCATION

Peking University Medical School, Beijing, China

Basic Medicine

State University of New York at Stony Brook, NY, USA

B.S. in Biochemistry University of California, Los Angeles, CA, USA

Ph.D. in Biochemistry

California Institute of Technology, Pasadena, CA, USA

Cell Cycle Regulation, Postdoctoral Fellow

Beckman Research Institute,

City of Hope, CA, USA

Pre-mRNA processing/cell cycle, Postdoctoral Fellow

PROFESSIONAL POSITIONS

2001–present Assistant, Associate, and Full Professor of Biology, Keck Science Department, Claremont McKenna College, Pitzer College, and Scripps College, Claremont, CA

2000–present Visiting Scientist, Molecular Biology Department, Beckman Research Institute of the City of Hope, Duarte, CA

2000–2001Interim Director of Molecular Biology Program and Assistant Professor, Biology Department, Pomona College, Claremont, CA