(

报告人：James Ferrell

    Professor of Chemical and Systems Biology;

    Professor of Biochemistry, Stanford University School of Medicine)

报告时间：12月7日（星期五）下午13:00-14:30

地  点：生科院邓祐才报告厅

摘  要：

The Xenopus early embryonic cell cycle is driven by oscillations in the concentration of cyclin B and inthe activity of cyclin B-Cdk1 complexes. We have been studying the Cdk1 oscillator through quantitative experiments and computational modeling. Here we show that the oscillator circuit includes a bistable trigger, built out of interlinked positive and double-negative feedback loops. This trigger allows the Cdk1 circuit to generate rapidly propagating waves of Cdk1 activation and inactivation, which help to keep mitosis coordinated over the large distance scales (~mm) of the frog egg