2012.12.7 Bistability and trigger waves in mitosis

2019-07-04 23:32:25



报告人:James Ferrell

    Professor of Chemical and Systems Biology;

    Professor of Biochemistry, Stanford University School of Medicine)


地  点:生科院邓祐才报告厅

摘  要:

The Xenopus early embryonic cell cycle is driven by oscillations in the concentration of cyclin B and inthe activity of cyclin B-Cdk1 complexes. We have been studying the Cdk1 oscillator through quantitative experiments and computational modeling. Here we show that the oscillator circuit includes a bistable trigger, built out of interlinked positive and double-negative feedback loops. This trigger allows the Cdk1 circuit to generate rapidly propagating waves of Cdk1 activation and inactivation, which help to keep mitosis coordinated over the large distance scales (~mm) of the frog egg