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实验室主页：http://cqb.pku.edu.cn/zenglab/ 电话：+86 010-62750092 E-mail: zexianzeng@pku(dot)edu(dot)cn |
学习经历：
2007-2011 北京理工大学，探测制导与控制技术,学士学位
2011-2014 威斯康星大学麦迪逊分校，计算机科学，工业工程，硕士学位
2014-2019 西北大学，生物医学信息学，博士学位
2019-2022 哈佛大学陈曾熙公共卫生学院，丹娜-法伯癌症研究所，博士后研究员
2022-至今 北京大学，定量生物学中心，生命科学联合中心，博士生导师
担任职务：
助理教授/研究员，博士生导师
北京大学定量生物学中心 (CQB)
北大-清华生命科学联合中心 (CLS)
北大-清华-NIBS联合培养项目(PTN)
研究方向：
生物信息、肿瘤免疫
细胞信号传导、基因表达调控
数据整合挖掘、机器学习方法与计算平台开发
研究兴趣：
聚焦生物信息学与肿瘤免疫学，通过整合挖掘肿瘤基因组学与医疗数据，并结合机器学习方法研究肿瘤免疫及信号通路调控，揭示肿瘤免疫反应机理，旨在为临床免疫治疗成功率的提高提供新的靶向基因，为免疫调控基因的发现提供新的研究思路，为临床肿瘤用药提供新的方法。
代表性文章：
Lijian Wu, Yiteng Jin, Xi Zhao, Kaiyang Tang, Yaoning Zhao, Linjie Tong, Xuerong Yu, Ke Xiong, Ce Luo, Jiajun Zhu, Fubing Wang*, Zexian Zeng*, Deng Pan*. Tumor aerobic glycolysis confers immune evasion through modulating sensitivity to T cell-mediated bystander killing via TNF-α. Cell Metabolism. July 27, 2023DOI:https://doi.org/10.1016/j.cmet.2023.07.001.
Zeng Z#, Gu S#, Wong C, Li D, Lin Y, Wong C, Ouardaoui N, Zhang W, Brown M, Liu XS: Machine learning on syngeneic mouse tumor profiles to model clinical immunotherapy response. Science Advances (2022) 10.1126.
Zeng Z*, Gu S*, Yang L, Wong C, Ouardaoui N, Zhang W, Li D, Weirather J, Zhang Y, Meyer C, Rodig S, Hodi SF*, Brown M*, Liu XS*: Hippo signaling pathway regulates cancer cell-intrinsic MHC-II expression. Cancer Immunology Research (2022) 10.1158.
Li Y#, Dennis S#, Hutch MR#, Li Y, Broad MS, Zeng Z*, Luo Y*. SOAR: a spatial transcriptomics analysis resource to model spatial variability and cell type interactions. bioRxiv (2022). 2022.04.17.488596.
Zeng Z#, Li Y#, Li Yi#, Luo Y: Computational methods for spatially resolved transcriptomics data analysis. Genome Biology (2022) 10.0265
Zeng Z*,#, Wong C#, Lin Y#, Li D, Zhang Y, Gu S, Zhang W, Kim S, Yates K, Freeman G, Brown M, Manguso R, Liu XS*: TISMO: syngeneic mouse tumor database to model tumor immunity and immunotherapy response. Nucleic Acids Research (2021) 10.1093
Zeng Z#, Fu J#, Cibulskis C, Jhaveri A, Gumbs C, Das B, … & Liu XS*, Wu C*: Cross-site concordance evaluation of tumor DNA and RNA sequencing platforms for the CIMAC-CIDC network. Clinical Cancer Research. (2021).20.3251
Kumar S#, Zeng Z#, Bagati A#, Tay Re#, Sanz L, Hartono SR, … & Liu XS*, Wucherpfennig K*: Carm1 inhibition enables immunotherapy of resistant tumors by dual action on tumor and T-cells. Cancer Discovery (2021). 20-1144
Zhou L#, Zeng Z#, Egloff A, Zhang F, Guo F, Cambell K, Du P, … & Liu XS*, Uppaluri R*: Checkpoint blockade induced CD8+ T cell differentiation in responders in head and neck cancers. Journal for ImmunoTherapy of Cancer (2021). 10 (1), e004034
Wang X, Tokheim C, Wang B, Gu S, Tang Q, li Y, Traugh N, Zeng Z, Zhang Y, Li Z, Zhang B, Fu J, …, Brown M*, Liu XS*: In vivo CRISPR screens identify E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target. Cell (2021) 09.006
Gu S#, Zhang W#, Wang X#, Jiang P, Traugh N, Li Z, Meyer C, … & Tewari AK, Zeng Z, … & Brown M*, Liu XS*: Therapeutically increasing MHC-I expression potentiates immune checkpoint blockade. Cancer Discovery. (2021) 20.0812
Cui Y, Cheng X, Chen Q, Song B, Chiu A, Gao Y, Dawson T, Chao L, Zhang W, Li D, Zeng Z, Yu J, Li Z, Fei T, Peng S, Li W: CRISP-view: a database of functional genetic screens spanning multiple phenotypes. Nucleic Acids Research. (2021).56(2)
Ranjan M, Lee O, Cottone G, Mirzaei Spike, Zeng Z., ... & Khan, S. A: Progesterone receptor antagonists reverse stem cell expansion and the paracrine effectors of progesterone action in the mouse mammary gland. Breast Cancer Research, (2021). 23(1), 1-17.
Zeng Z, Vo A, Li X, Shidfar Ali, Saldana P, Xuei X, Luo Y, Khan AS, Clare SE: Somatic genetic aberrations in benign breast disease and the risk of subsequent breast cancer. npj Breast Cancer. (2020). 6(1),1-11
Zeng Z, Amin A, Roy A, Pulliam N, Karavites L, Espino S, Li X, Luo Y, Khan AS: Preoperative magnetic resonance imaging and oncologic outcomes in premenopausal breast cancer patients. npj Breast Cancer. (2020). 6(1),1-8.
Zeng Z, Fan Z, Xie X, Swartz C, DePriest P, Li J: A two-level iteration approach for modeling and analysis of rapid response process with multiple deteriorating patients. Flexible Service and Manufacturing. (2020). 1-37
Zeng Z, Mao C, Vo A, Li X, Nugene J, Khan AS, Clare SE, Luo Y: Deep learning for cancer type classification and driver gene identification. BMC Bioinformatics. (2020) (18)1
Gu S#, Wang X#, Hu X, Jiang P, Li Z, Traugh N, Bu X, Tang Q, Wang C, Zeng Z, Fu J, Meyer C, … & Brown M*, Liu XS*: Clonal Tracing reveals diverse patterns of response to immune checkpoint blockade. Genome Biology. (2020). 10-118
Li T, Fu J, Zeng Z, Cohen D, Li J, Chen Q, Li B, Liu XS: TIMER2.0 for Analysis of Tumor-Infiltrating Immune Cells. Nucleic Acids Research. (2020). 48(1)
Lee, O, Sullivan M, Xu Y, Rogers C, Muzzio M, Helenowski I, Shidfar A, Zeng Z, Hansen, N, etc., Khan S: Selective progesterone receptor modulators in early-stage breast cancer: a randomized, placebo-controlled phase II window-of-opportunity trial using telapristone acetate. Clinical Cancer Research. (2020). 26(1), 25-34
Zeng Z, Vo A, Mao C, Clare S, Khan S, Luo Y: Cancer classification and pathway discovering using non-negative matrix factorization. Journal of Biomedical Informatics. (2019): 103247
Zeng Z, Yao L, Roy A, Li X, Espino S, Clare S, Khan S, Luo Y: Identifying breast cancer distant recurrence from electronic health records using machine learning. Journal of Healthcare Informatics Research. (2019). 1-17
Chen N, Xie X, Zeng Z, Zhong X, Brenny-Fitzpatrick M, Liegel B, Zheng L, Li J: Improving discharge process at the University of Wisconsin Hospital: a system-theoretic method. IEEE Transactions on Automation Science and Engineering. (2019) 7(45)Zimmerman L, Reyfman P, Smith A, Zeng Z, Kho A, Sanchez-pinto L Luo Y: Early prediction of acute kidney injury following ICU admission. BMC Medical Informatics and Decision Making. (2019). 19(1),16
Zeng Z, Xie X, Menaker H, Sanford-Ring SG, Li J: Performance evaluation of operating room schedules in orthopedic surgery. Flexible Services and Manufacturing. (2018), 30(1-2):198-223.
Zeng Z, Deng Y, Li X, Naumann T, Luo Y: Natural language processing for EHR-based computational phenotyping. IEEE/ACM Transactions on Computational Biology and Bioinformatics. (2018):1-1
Zeng Z, Espino S, Roy A, Li X, Khan S, Clare S, Jiang X, Neapolitan R, Luo Y: Using natural language processing and machine learning to identify breast cancer local recurrence. BMC Bioinformatics. (2018), 19(Suppl 17):498
Luo Y, Thompson WK, Herr TM, Zeng Z, Berendsen MA, Jonnalagadda SR, Carson MB, Starren J: Natural language processing for EHR-based pharmacovigilance: a structured review. Drug Safety. (2017):1-15
Zeng Z, Jiang X, Neapolitan R: Discovering causal interactions using Bayesian network scoring and information gain. BMC bioinformatics, (2016), 17(1):1.
获奖情况：
AMIA (American Medical Informatics Association)学会最佳博士论文奖
