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博士生导师 电子信箱:linjie@pku.edu.cn 课题组主页:http://cqb.pku.edu.cn/jlingroup 2007-2011,复旦大学,物理学学士 2011-2016,纽约大学,物理学博士 2016-2020, 哈佛大学,博士后 |
担任职务:
北京大学前沿交叉学科研究院研究员
北京大学定量生物学中心研究员
北京大学-清华大学生命科学联合中心研究员
研究方向:
理论生物物理,定量生物学,软物质物理,系统生物学
对我的研究感兴趣的同学可以邮件联系我,了解博士后,研究生,和本科生的科研机会。
研究兴趣:
我的主要研究方向是理论生物物理 (theoretical biological physics),也就是通过物理的语言去描述和理解复杂生物系统。我关注的对象通常是生物系统中被广泛观察到的现象。这些现象往往普遍存在于不同物种中。近期感兴趣的问题包括 (1) 基因表达 (gene expression) 的普适规律,(2) 活性软物质物理 (soft living matter), (3) 微生物生理学 (microbial physiology)。通常我的研究目标是构建一个统一的数学模型去理解那些现象,同时能够做出新的可以被实验验证的理论预言。
构建一个描述生物系统的数学模型是具有挑战性的,因为这个模型必须抓住问题的关键元素,并且摒弃无关的细节。在凝聚态物理里面,找到这样的关键变量通常不是很困难,因为被研究的系统在空间上经常是足够均匀的。然而,在生物系统里,被研究的对象往往要复杂得多且是非常不均匀的(想象一下有各种细胞器且充满各种各样生物分子的真核细胞)。因此,想要在生物系统中找到问题的关键变量经常不是显而易见的,甚至是需要物理直觉的。对于物理学家来说,这或许是生物物理这门交叉学科最有趣的地方。
代表性论文:
16. Heterogeneous elasticity drives ripening and controls bursting kinetics of transcriptional condensates
Lingyu Meng, Sheng Mao, Jie Lin
Proceedings of the National Academy of Sciences (PNAS), 121 (12), e2316610121, 2024
15. Fingering instability accelerates population growth of a proliferating cell collective
Yiyang Ye, Jie Lin
Physical Review Letters, 132, 018402, 2024
14. Diffusion enhancement in bacterial cytoplasm through an active random force
Lingyu Meng, Yiteng Jin, Yichao Guan, Jiayi Xu, Jie Lin
Physical Review Research, 5, L032018, 2023
13. Implications of differential size-scaling of cell-cycle regulators on cell size homeostasis
Xiangrui Ji, Jie Lin
PLOS Computational Biology, 19, 1-24, 2023
12. Cell Size: Putting scaling laws on a physical foundation
Yiyang Ye, Jie Lin
eLife, 12, e89415, 2023
11. Indissoluble biomolecular condensates via elasticity
Lingyu Meng, Jie Lin
Physical Review Research, 5, L012024, 2023
10. Environment-specificity and universality of the microbial growth law
Qirun Wang, Jie Lin
Communications Biology, 5, 891, 2022
9. Modeling the aging of protein condensates
Jie Lin
Physical Review Research, 4, L022012, 2022
8. Coupling between DNA replication, segregation, and the onset of constriction in Escherichia coli
Sriram Tiruvadi-Krishnan, Jaana Männik, Prathitha Kar, Jie Lin, Ariel Amir, Jaan Männik
Cell Reports, 38, 110539, 2022
7. Heterogeneous recruitment abilities to RNA polymerases generate nonlinear scaling of gene expression with cell volume
Qirun Wang, Jie Lin
Nature Communications, 12, 6852, 2021
6. Disentangling intrinsic and extrinsic gene expression noise in growing cells
Jie Lin, Ariel Amir
Physical Review Letters, 126, 078101, 2021
5. Evolution of microbial growth traits under serial dilution
Jie Lin, Michal Manhart, Ariel Amir
Genetics, 215, 767-777, 2020
4. Optimal segregation of proteins: phase transitions and symmetry breaking
Jie Lin, Jiseon Min, Ariel Amir
Physical Review Letters, 122, 068101, 2019
3. Homeostasis of protein and mRNA concentrations in growing cells
Jie Lin, Ariel Amir
Nature Communications, 9, 4496, 2018
2. Modeling cell size regulation: From single-cell level statistics to molecular mechanisms and population-level effects
Po-Yi Ho, Jie Lin, Ariel Amir,
Annual Review of Biophysics, 47, 2018
1. The effects of stochasticity at the single-cell level and cell size control on the population growth
Jie Lin, Ariel Amir
Cell Systems, 5(4):358-367, 2017
获奖情况:
George F. Carrier Postdoctoral Fellowship, Harvard University
Horizon Fellowship, New York University