北京大学定量生物学中心
学术报告
题 目: Three Dimensional structures determine fast dynamics between distal loci pairs in Interphase Chromosomes
报告人: 时光 博士
Department of Chemistry, the University of Texas at Austin
时 间: 11月25日（周一）13:00-14:00
地 点: 线上Zoom会议
会议号: 894 5959 6706
密码: 123456
https://zoom.us/j/89459596706?pwd=yHPlLUUCqe2Kw956NsnwV3gB3sUY0a.1
主持人: 韩铭 研究员
摘要:
Chromatin's three-dimensional organization plays a pivotal role in regulating gene expression and genome function, yet linking static snapshots of chromatin structure to its dynamic behavior remains a challenge. I will present the HIPPS-DIMES computational method, which employs the maximum-entropy principle to construct detailed chromatin structures from static contact data. Building upon this structural foundation, we derive a connectivity matrix representing effective interactions between chromatin loci and utilize this within a generalized polymer dynamics framework to predict chromatin dynamics. This approach reveals how three-dimensional organization influences motion and relaxation processes, accurately reproducing experimental observations and resolving discrepancies—such as underestimated relaxation times—with traditional polymer models. I will discuss how incorporating long-range interactions and hierarchical chromatin organization in our model sheds light on essential biological processes, including enhancer-promoter interactions and the role of architectural proteins like cohesin. By linking chromatin structure and dynamics, our model opens new avenues for exploring chromatin behavior and may inform future studies on genome organization and regulation.
报告人简介：
Dr. Guang Shi is a research associate at the Department of Chemistry at the University of Texas at Austin. He is broadly interested in the physical principles that underlie genome organization and biomolecular condensates and their biological functions. Previously he has worked with Dr. Kenneth S. Schweizer at University of Illinois at Urbana-Champaign on phase behavior and rheology of biomolecular condensates. He got my Ph.D. in Biophysics from University of Maryland at College Park.
