北京大学定量生物学中心/生命科学学院
学术报告
题 目: SMC-based genome management beyond double stranded DNA
报告人: Professor Xiaolan Zhao
Member & Laboratory Head
Molecular Biology Program
Memorial Sloan Kettering Cancer Center
时 间: 10月11日（周五）13:00-14:30
地 点: 生命科学学院邓祐才报告厅
主持人: 李晴 教授 & 齐志 研究员
摘要:
SMC (Structural Maintenance of Chromosomes) complexes play essential roles as genome regulators in both prokaryotes and eukaryotes. The Dr. Xiaolan Zhao earned her BSc in Biology from Peking University and her DPhil in Genetics and Development from the Columbia University. She then worked as a postdoc at the Rockefeller University. In 2006, she joined the Weill Cornell Graduate School of Medical Sciences and Gerstner Sloan-Kettering Graduate School as an assistant professor and became a professor in 2016. Her lab investigates 3R(DNA replication, repair, and damage response, collectively called the 3Rs)mechanisms, 3R protein functions and structures, and their links to human disease.canonical functions of SMCs include organizing DNA into domains and structures, packing the genome into the nucleus, and compacting DNA into chromosomes. These roles are most evident for eukaryotic cohesin and condensin SMCs. In contrast, the third eukaryotic SMC, the Smc5/6 complex, has been discovered to participate in regulating DNA replication and genome repair, as well as restraining viral circular DNA. We and others have placed Smc5/6 in the processes of promoting leading strand synthesis, preventing replication fork reversal, and facilitating the removal of recombinational repair intermediates. How can Smc5/6 carry out the diverse functions identified thus far? Our recent collaborative efforts combine cryo-EM and single-molecule approaches with functional studies to elucidate the unique features of Smc5/6 that are distinct from cohesin and condensin, and how these features could explain that its functional mechanisms. These characteristics offer insights into how Smc5/6 functions as one of the most versatile factors for genome maintenance and protection.
报告人简介：
Dr. Xiaolan Zhao earned her BSc in Biology from Peking University and her DPhil in Genetics and Development from the Columbia University. She then worked as a postdoc at the Rockefeller University. In 2006, she joined the Weill Cornell Graduate School of Medical Sciences and Gerstner Sloan-Kettering Graduate School as an assistant professor and became a professor in 2016. Her lab investigates 3R(DNA replication, repair, and damage response, collectively called the 3Rs)mechanisms, 3R protein functions and structures, and their links to human disease.
