定量生物学中心
2025年发表论文
3D facial imaging: a novel approach for metabolic abnormalities risk profiling
Qianqian Peng, Yam Ki Cheung, Yu Liu, Yiyang Wang, Jingze Tan, Yajun Yang, Jiucun Wang, Jing-Dong J. Han, Li Jin, Fan Liu, Sijia Wang.
Science China-Life Sciences, 2025, 68(6), p. 1786-1800. [Html]
Accelerating discovery of bioactive ligands with pharmacophore-informed generative models
Weixin Xie, Jianhang Zhang, Qin Xie, Chaojun Gong, Yuhao Ren, Jin Xie, Qi Sun, Youjun Xu, Luhua Lai, Jianfeng Pei.
Nature Communications, 2025, 16(1). [Html]
AI-enabled directed evolution for protein engineering and optimization
Chengzhi Song, Yihan Lin.
Synthetic Biology Journal, 2025, 6(3), p. 617-635. [Html]
Amelioration effects of Cajanus cajan extracts and the active ingredient pinostrobin on hyperuricemia and related kidney injury
Xiancai Li, Wanjie Yu, Liyuan Yao, Fen Liu, Yongqing Li, Binghong Xiong, Jin Xie, Sheng-Xiang Qiu.
Food & Function, 2025. [Html]
APP ubiquitination by VHL protein is essential for MVB sorting and lysosomal degradation
Chunyan Shan, Rixu Cong, Xiangyu Xu, Yuanjun Li, Yonglu Tian, Wenyuan Cao, Wei Zhao, Linqing Miao, Junlin Teng, Ning Huang, Jianguo Chen.
Journal of molecular cell biology, 2025. [Html]
Application and prospect of live cell DNA-based molecular recorders in cell lineage tracing
Baiyi Jiang, Long Qian.
Synthetic Biology Journal, 2025, 6(3), p. 651-668. [Html]
Artificial design and clinical applications of the cytokine signaling system
Siqi Jiang, Jialing Zhou, Annan Feng, Haibang Lei, Wei Guo, Miao Wang, Yuanxu Jiang, Ping Wei.
Chinese Bulletin of Life Sciences, 2025, 37(8), p. 992-1006. [Html]
Artificial intelligence guided Raman spectroscopy in biomedicine: Applications and prospects
Yuan Liu, Sitong Chen, Xiaomin Xiong, Zhenguo Wen, Long Zhao, Bo Xu, Qianjin Guo, Jianye Xia, Jianfeng Pei.
Journal of Pharmaceutical Analysis, 2025, 15(11). [Html]
An Automated Multi-Sample Digital LAMP Platform for Quantitative Detection of SDC2 Methylation in Colorectal Cancer
Hao He, Yanzhao Wu, Wei Lai, Lin Zhou, Zhirui Liu, Nan Rong, Chunxiong Luo, Chanqiong Zhang, Wei Yang.
Analytical Chemistry, 2025, 97(39), p. 21438-21448. [Html]
Balancing reaction-diffusion network for cell polarization pattern with stability and asymmetry
Yixuan Chen, Guoye Guan, Lei-Han Tang, Chao Tang.
Elife, 2025, 13. [Html]
Benchmarking Cofolding Methods for Molecular Glue Ternary Structure Prediction
Yiyan Liao, Jintao Zhu, Juan Xie, Luhua Lai, Jianfeng Pei.
Journal of Chemical Information and Modeling, 2025, 65(20), p. 11136-11148. [Html]
Biomedical data and AI
Hao Xu, Shibo Zhou, Zefeng Zhu, Vincenzo Vitelli, Liangyi Chen, Ziwei Dai, Ning Yang, Luhua Lai, Shengyong Yang, Sergey Ovchinnikov, Zhuoran Qiao, Sirui Liu, Chen Song, Jianfeng Pei, Han Wen, Jianfeng Feng, Yaoyao Zhang, Zhengwei Xie, Yang-Yu Liu, Zhiyuan Li, Fulai Jin, Hao Li, Mohammad Lotfollahi, Xuegong Zhang, Ge Yang, Shihua Zhang, Ge Gao, Pulin Li, Qi Liu, Jing-Dong Jackie Han.
Science China-Life Sciences, 2025, 68(5), p. 1536-1540. [Html]
Cell lineage-resolved embryonic morphological map reveals signaling associated with cell fate and size asymmetry
Guoye Guan, Zelin Li, Yiming Ma, Pohao Ye, Jianfeng Cao, Ming-Kin Wong, Vincy Wing Sze Ho, Lu-Yan Chan, Hong Yan, Chao Tang, Zhongying Zhao.
Nature Communications, 2025, 16(1). [Html]
Characterizing biomarkers of ageing in Singaporeans: the ABIOS observational study protocol
Jessica K. Lu, Weilan Wang, Janjira Soh, Elena Sandalova, Zhi Meng Lim, Santosh Kumar Seetharaman, Jing-Dong Jackie Han, Desmond B. Teo, Brian K. Kennedy, Jorming Goh, Andrea B. Maier.
Geroscience, 2025, 47(3), p. 3997-4008. [Html]
Computer-Aided Drug Discovery for Undruggable Targets
Qi Sun, Hanping Wang, Juan Xie, Liying Wang, Junxi Mu, Junren Li, Yuhao Ren, Luhua Lai.
Chemical Reviews, 2025, 125(13), p. 6309-6365. [Html]
A conserved H3K14ub-driven H3K9me3 for chromatin compartmentalization
Yuanyong Huang, Yimei Sun, Hongyun Qi, Quanlong Jiang, Jialun Li, Mingzhi Chang, Xinyan Li, Lei Shu, Xiaoya Duan, Yiqin Wang, Kailun Fang, Hailei Mao, Mengmeng Han, Yuan Weng, Qiao Zhang, Zhaosu Chen, Wei Wei, Gaojie Song, Qiansen Zhang, Jiwen Li, Jing-Dong J. Han, Charlie Degui Chen, Jiemin Wong.
Nature, 2025, 647(8090). [Html]
Conversion of placental hemogenic endothelial cells to hematopoietic stem and progenitor cells
Guixian Liang, Shicheng Liu, Chunyu Zhou, Mengyao Liu, Yifan Zhang, Dongyuan Ma, Lu Wang, Jing-Dong J. Han, Feng Liu.
Cell Discovery, 2025, 11(1). [Html]
Criticality in the Luria-Delbruck Model with an Arbitrary Mutation Rate
Deng Pan, Jie Lin, Ariel Amir.
Physical Review Letters, 2025, 134(3). [Html]
Custom-Primed Rolling Circle Amplicons for Highly Accurate Nanopore Sequencing
Jiayi Zhang, Xujuan Yang, Weijia Xuan, Zhiguang Wu, Jiawei Ding, Zhenqi Wang, Qi Yan, Tianqing Zhang, Zhi Qi, Jingwei Bai, Bryan Wei.
Small Methods, 2025, 9(6). [Html]
De novo design of insulated cis-regulatory elements based on deep learning-predicted fitness landscape
Haochen Wang, Yanhui Xiang, Ziming Liu, Wen Yin, Boyan Li, Long Qian, Xiaowo Wang, Chunbo Lou.
Nucleic Acids Research, 2025, 53(12). [Html]
Deciphering Ca2+permeation and valence selectivity in CaV1: Molecular dynamics simulations reveal the three-ion knock-on mechanism
Lingfeng Xue, Nieng Yan, Chen Song.
Proceedings of the National Academy of Sciences of the United States of America, 2025, 122(22). [Html]
Deciphering cell-fate trajectories using spatiotemporal single-cell transcriptomic data
Zhenyi Zhang, Zihan Wang, Yuhao Sun, Jiantao Shen, Qiangwei Peng, Tiejun Li, Peijie Zhou.
NPJ systems biology and applications, 2025. [Html]
Deciphering gene redundancy in prokaryotic genomes provides evolutionary insights for pathogenicity and its roles in clinical infections
Peihong Wang, Qian Guo, Xiaoqing Jiang, Ping Lu, Mengru Chang, Longshu Yang, Mo Li, Chunhui Wang, Tingting Xiao, Yonghong Xiao, Huaiqiu Zhu.
Nature Communications, 2025, 16(1). [Html]
Deciphering the molecular mechanisms of FET fusion oncoprotein-DNA hollow co-condensates
Linyu Zuo, Qirui Guo, Cheng Li, Kecheng Zhang, Yancao Chen, Baiyi Jiang, Zhixing Chen, Yufei Xia, Long Qian, Lei Zhang, Zhi Qi.
Nature Communications, 2025, 16(1). [Html]
Decoding cell fate: integrated experimental and computational analysis at the single-cell level
Yutong Zhou, Shuyang Hou, Xinhao Miao, Guangxin Zhang, Zining Li, Di Zhang, Yongjie Lin, Yihan Lin.
Bioinformatics, 2025, 41(11). [Html]
Design principles and artificial synthesis of biological oscillators
Yuanxu Jiang, Yingying Fan, Ping Wei.
Synthetic Biology Journal, 2025, 6(3), p. 516-531. [Html]
DiffPepDock: Efficient protein-peptide docking and binder screening via SE(3)-equivariant diffusion
Yuzhe Wang, Fanhao Wang, Laiyi Feng, Changsheng Zhang, Luhua Lai.
Protein Science, 2025, 34(11). [Html]
Dimerization and substrate recognition of human taurine transporter
Yimin Zhang, Jiahui Chen, Nanhao Chen, Haolin Xiong, Zhengjiang Zhu, Dongxue Yang, Jingpeng Ge, Jie Yu.
Nature Communications, 2025, 16(1). [Html]
Discovery of diverse and high-quality mRNA capping enzymes through a language model-enabled platform
Tianze Wang, Bowen R. Qin, Sihong Li, Zimo Wang, Xuejian Li, Yuanxu Jiang, Chenrui Qin, Qi Ouyang, Chunbo Lou, Long Qian.
Science Advances, 2025, 11(15). [Html]
Discovery of RNA-Targeting Small Molecules: Challenges and Future Directions
Zhengguo Cai, Hongli Ma, Fengcan Ye, Dingwei Lei, Zhenfeng Deng, Yongge Li, Ruichu Gu, Han Wen.
Medcomm, 2025, 6(9). [Html]
Distinct Phage-Encoded Enzymes for Substitution of Deoxythymidine by Deoxyuridine in Phage Genomes
Yating Li, Jason Tan, Yanqin Tu, Jingnan Wu, Zaifang Zhang, Yifeng Wei, Xinan Jiao, Yan Zhou.
Advanced Science, 2025. [Html]
DLGAP5 enhances bladder cancer chemoresistance by regulating glycolysis through MYC stabilization
Zhao Deng, Fenfang Zhou, Mingxing Li, Wan Jin, Jingtian Yu, Gang Wang, Kaiyu Qian, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang.
Theranostics, 2025, 15(6), p. 2375-2392. [Html]
The DNA methylation-demethylation balance prevents development of multiple megaspore mother cells in Arabidopsis
Ting Jiang, Lei Li, Qianqian Hu, Xianyu Kuang, Lei Zhang, Wenjie Zeng, Daisuke Miki, Binglian Zheng.
Plant Cell, 2025, 37(2). [Html]
Dynamic phosphorylation of MIS12 ensures accurate kinetochore-microtubule attachment by expanding the fibrous corona
Qi Li, Qingzhou Chen, Tao Zheng, Junlin Teng, Haining Zhou, Jianguo Chen.
Molecular Biology of the Cell, 2025, 36(8). [Html]
Dynamic TOM-TIM23 supercomplex directs mitochondrial protein translocation and sorting
Yuqi Yang, Shanshan Wang, Guopeng Wang, Yuke Lian, Lingfeng Xue, Wenhong Jiang, Qiang Guo, Chen Song, Long Li.
Nature Structural & Molecular Biology, 2025. [Html]
Dynamics-based drug discovery by time-resolved cryo-EM
Youdong Mao.
Current Opinion in Structural Biology, 2025, 91. [Html]
An effective method for quantification, visualization, and analysis of 3D cell shape during early embryogenesis
Zelin Li, Zhaoke Huang, Jianfeng Cao, Guoye Guan, Zhongying Zhao, Hong Yan.
Quantitative Biology, 2025, 13(1), p. e83. [Html]
Engineering virus-like particles for safe and versatile modeling of SARS-CoV-2 host interaction and immune escape
Liang Ma, Yuan Lin, Siyu Ma, Kai Chen, Yihan Lin.
Communications Biology, 2025, 8(1). [Html]
Exploring the repository of de novo-designed bifunctional antimicrobial peptides through deep learning
Ruihan Dong, Rongrong Liu, Ziyu Liu, Yangang Liu, Gaomei Zhao, Honglei Li, Shiyuan Hou, Xiaohan Ma, Huarui Kang, Jing Liu, Fei Guo, Ping Zhao, Junping Wang, Cheng Wang, Xingan Wu, Sheng Ye, Cheng Zhu.
Elife, 2025, 13. [Html]
FBXW7/GSK3β-mediated proline-rich 11 degradation promotes oxidative DNA damage and inhibits tumor progression in renal cell carcinoma
Siming Chen, Kangping Xiong, Jianmin Liu, Shijie Yao, Mingxing Li, Jingtian Yu, Gang Wang, Sheng Tu, Wan Jin, Jiageng Shi, Yu Xiao, Yi Zhang, Kaiyu Qian, Lingao Ju, Xinghuan Wang.
Theranostics, 2025, 15(7), p. 2814-2833. [Html]
Forging the iron-net: Towards a quantitative understanding of microbial communities via siderophore-mediated interactions
Shaohua Gu, Jiqi Shao, Ruolin He, Guanyue Xiong, Zeyang Qu, Yuanzhe Shao, Linlong Yu, Di Zhang, Fanhao Wang, Ruichen Xu, Peng Guo, Ningbo Xi, Yinxiang Li, Yanzhao Wu, Zhong Wei, Zhiyuan Li.
Quantitative Biology, 2025, 13(2), p. e84. [Html]
Foveal vision reduces neural resources in agent-based game learning
Runping Chen, Gerd J. Kunde, Louis Tao, Andrew T. Sornborger.
Frontiers in Neuroscience, 2025, 19. [Html]
Functional Genetic Screens Reveal Key Pathways Instructing the Molecular Phenotypes of Tumor-Associated Macrophages
Youxue Lu, Ce Luo, Lanxiang Huang, Gengyi Wu, Lihan Zhong, Jieyu Chu, Fubing Wang, Zexian Zeng, Deng Pan.
Cancer Immunology Research, 2025, 13(12), p. 2054-2074. [Html]
Genetic Deconvolution of Embryonic and Maternal Cell-Free DNA in Spent Culture Medium of Human Preimplantation Embryo Through Deep Learning
Zhenyi Zhang, Jie Qiao, Yidong Chen, Peijie Zhou.
Advanced Science, 2025, 12(34). [Html]
Genomic epidemiology and phylodynamics of Acinetobacter baumannii bloodstream isolates in China
Qixia Luo, Mengru Chang, Ping Lu, Qian Guo, Xiaoqing Jiang, Tingting Xiao, Haoyu Zhang, Yingying Ma, Yan Zhang, Wei Yu, Erjia Zhang, Yunbo Chen, Ping Shen, Jinru Ji, Chaoqun Ying, Zhiying Liu, Huaiqiu Zhu, Yonghong Xiao.
Nature Communications, 2025, 16(1). [Html]
GeoEvoBuilder: A deep learning framework for efficient functional and thermostable protein design
Jiale Liu, Hantian You, Zheng Guo, Qin Xu, Changsheng Zhang, Luhua Lai.
Proceedings of the National Academy of Sciences of the United States of America, 2025, 122(41). [Html]
Geometry of Optimal Control in Chemical Reaction Networks in the Adiabatic Limit
Yikuan Zhang, Qi Ouyang, Yuhai Tu.
Physical Review Letters, 2025, 134(1). [Html]
Gold/Prussian Blue-Based Nanocomposites with Dual Nanozyme Activities Exert a Synergistic Effect of Starvation Therapy and Sonodynamic Therapy in the Treatment of Liver Cancer
Shengnan Huang, Chengzhi Song, Tengyue Zhao, Yefei Yang, Zhiwei Yao, Shaofeng Duan, Wanyi Chen, Lixian Li, Xiaogang Hu, Chunming Li, Yurong Hu.
International Journal of Nanomedicine, 2025, 20, p. 10721-10737. [Html]
GPx4 is bound to peroxidized membranes by a hydrophobic anchor
Qingyang Hu, Hantian You, Kenan Li, Luhua Lai, Chen Song.
Journal of Molecular Biology, 2025, 437(12). [Html]
Heat syndrome types prediction of traditional Chinese medicine in acute ischemic stroke through deep learning: a pilot study
Xiongwu Yu, Lingqian He, Qi Wang, Zhongyun Zhang, Huaiqiu Zhu, Juexian Song.
Frontiers in Pharmacology, 2025, 16. [Html]
Hollow condensates emerge from gelation-induced spinodal decomposition
Cheng Li, Lingyu Meng, Yongxin Tong, Jie Lin, Zhi Qi.
Proceedings of the National Academy of Sciences, 2025, 122(52), p. e2520491122. [Html]
De Novo Design of Cyclic Peptide Binders Based on Fragment Docking and Assembling
Changsheng Zhang, Fanhao Wang, Tiantian Zhang, Yang Yang, Liying Wang, Xiaoling Zhang, Luhua Lai.
Journal of Chemical Information and Modeling, 2025, 65(8), p. 4206-4218. [Html]
Multiple-Basin Go-Martini for Investigating Conformational Transitions and Environmental Interactions of Proteins
Song Yang, Chen Song.
Journal of Chemical Theory and Computation, 2025, 21(10), p. 5304-5321. [Html]
Identification and Functional Disparity of Pheromone-Binding Proteins from Tomato Leafminer Tuta absoluta in Detection of Sex Pheromone Components
Liu Zhang, Shuo Yang, Jin Xie, Hongwei Li, Wangpeng Shi, Jianfeng Pei, Yanxue Yu, Junfeng Zhai.
Journal of Agricultural and Food Chemistry, 2025, 73(40), p. 25316-25328. [Html]
Identification of gut microbial bile acid metabolic enzymes via an AI-assisted pipeline
Yong Ding, Xi Luo, Jiasheng Guo, Baiying Xing, Haoyu Lin, Haohan Ma, Yicun Wang, Meng Li, Chuan Ye, Sen Yan, Kangjie Lin, Jinxin Zhang, Yingying Zhuo, Qixing Nie, Donghui Yang, Zhipeng Zhang, Yanli Pang, Kai Wang, Ming Ma, Luhua Lai, Changtao Jiang.
Cell, 2025, 188(21), p. 6012-6027. [Html]
Impact of a Terahertz electromagnetic field on the ion permeation of potassium and sodium channels
Zigang Song, Lingfeng Xue, Qi Ouyang, Chen Song.
Communications Chemistry, 2025, 8(1). [Html]
In-situ cross-linking mass spectrometry reveals compartment-specific proteasomal interactions and structural heterogeneity
Lili Zhao, Runtao Zhao, Zhou Gong, Fuxiang Liang, Nan Zhao, Bowen Zhong, Maili Liu, Yukui Zhang, Qun Zhao, Lihua Zhang, Chun Tang.
Nature Communications, 2025, 16(1). [Html]
Innovations in aging biology: highlights from the ARDD emerging science & technologies workshop
Maximilian Unfried, Tomas Schmauck-Medina, Neal D. Amin, Edward S. Boyden, Georg Fuellen, Jing-Dong Jackie Han, Jacob H. Hanna, Indra Heckenbach, Konstantin Khodosevich, Lisa Melton, Emad Moeendarbary, Tae Seok Moon, Shahaf Peleg, Anders Sandberg, Lingyan Shi, Daniela Bakula, Alex Zhavoronkov, Morten Scheibye-Knudsen.
Npj Aging, 2025, 11(1). [Html]
Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells
Ce Luo, Rui Zhang, Rui Guo, Lijian Wu, Teng Xue, Yufeng He, Yiteng Jin, Yanping Zhao, Zongxu Zhang, Peng Zhang, Sitong Ye, Xiaohong Li, Dian Li, Wubing Zhang, Chenfei Wang, Luhua Lai, Qiang Pan-Hammarstrom, Kai W. Wucherpfennig, Zhidong Gao, Deng Pan, Zexian Zeng.
Immunity, 2025, 58(3), p. 745-765. [Html]
Integrating Dynamical Systems Modeling with Spatiotemporal scRNA-Seq Data Analysis
Zhenyi Zhang, Yuhao Sun, Qiangwei Peng, Tiejun Li, Peijie Zhou.
Entropy, 2025, 27(5). [Html]
A kinetic model for USP14 regulated substrate degradation in 26S proteasome
Di Wu, Qi Ouyang, Hongli Wang, Youdong Mao.
Plos Computational Biology, 2025, 21(5). [Html]
Low-burden and precursor-free cell-cell communication in mammalian cells enabled by denovo design of super-sensitive intercellular signals
Zhi Sun, Yanhui Xiang, Yukui Pan, Min Yu, Long Qian, Qi Ouyang, Chunbo Lou.
Cell systems, 2025, 16(12), p. 101475-101475. [Html]
Mechanism-Driven Screening of Membrane-Targeting and Pore-Forming Antimicrobial Peptides
Jiaxuan Li, Chenguang Yang, Ruihan Dong, Juan Francisco Bada Juarez, Lei Wang, Maximilian Emanuel Wettstein, Dali Wang, Chan Cao, Ying Lu, Chen Song.
Advanced Science, 2025. [Html]
Mechanistic insights into the acetyl-CoA recognition by SLC33A1
Dong Zhou, Nanhao Chen, Shitang Huang, Chen Song, Zhe Zhang.
Cell Discovery, 2025, 11(1). [Html]
Mechanistic Insights Into the Assembly of Functional CRL3 Dimeric Complexes
Weize Wang, Zonglin Dai, Ling Liang, Youdong Mao, Yuxin Yin.
Bioessays, 2025, 47(6). [Html]
Mechanistic insights into the orthogonal functionality of an AHL-mediated quorum-sensing circuit in Yersinia pseudotuberculosis
Boyu Luo, Shanshan Wu, Wei Liu, Dongdong Zhang, Ruicun Liu, Tuoyu Liu, Zhi Sun, Ziqun Wei, Mingyu Liu, Zhiyuan Shi, Niu Huang, Yue Teng.
Synthetic and Systems Biotechnology, 2025, 10(1), p. 174-184. [Html]
The membrane-proximal external region of human immunodeficiency virus (HIV-1) envelope glycoprotein trimers in A18-lipid nanodiscs
Yi Qi, Shijian Zhang, Kunyu Wang, Haitao Ding, Zhiqing Zhang, Saumya Anang, Hanh T. Nguyen, John C. Kappes, Joseph Sodroski, Youdong Mao.
Communications Biology, 2025, 8(1). [Html]
MGTbind: a comprehensive database of molecular glue ternary interactome
Jintao Zhu, Yiyan Liao, Haoyu Lin, Juan Xie, Zhichao Deng, Jinyu Han, Zhen Zhang, Jinchuan Xiao, Zhiyao Wang, Shuaipeng Zhang, Luhua Lai, Jianfeng Pei.
Nucleic Acids Research, 2025. [Html]
Microbial siderophotes for One Health
Zhong Wei, Shaohua Gu, Vera Vollenweider, Yuanmei Zuo, Zhiyuan Li, Rolf Kummerli.
Trends in Microbiology, 2025, 33(12), p. 1277-1285. [Html]
Minimizing information loss reduces spiking neuronal networks to differential equations
Jie Chang, Zhuoran Li, Zhongyi Wang, Louis Tao, Zhuo-Cheng Xiao.
Journal of Computational Physics, 2025, 537. [Html]
MMFuncPhos: A Multi-Modal Learning Framework for Identifying Functional Phosphorylation Sites and Their Regulatory Types
Juan Xie, Ruihan Dong, Jintao Zhu, Haoyu Lin, Shiwei Wang, Luhua Lai.
Advanced Science, 2025, 12(9). [Html]
Modeling liquid-liquid phase separation and its impact on proteasomal substrate degradation
Di Wu, Ouyang Qi, Hongli Wang.
Computational and Structural Biotechnology Journal, 2025, 27, p. 5263-5270. [Html]
Modeling phase separation of biomolecular condensates with data-driven mass-conserving reaction-diffusion systems
Cheng Li, Man-Ting Guo, Xiaoqing He, Quan-Xing Liu, Zhi Qi.
Structure, 2025, 33(9), p. 1519-1532. [Html]
Modeling protein-ligand interactions for drug discovery in the era of deep learning
Yuzhe Wang, Yibo Li, Jiaxiao Chen, Luhua Lai.
Chemical Society Reviews, 2025, 54(23), p. 11141-11183. [Html]
Nanocluster intermediates orchestrate the phase transition of ATP condensates
Zihan Li, Tairan Yuwen, Chun Tang.
Communications chemistry, 2025. [Html]
Natural variation in CHELATASE SUBUNIT I-A increases grain weight and enhances wheat yield
Bo Wei, Yike Liu, Mingjie Lyu, Rui Chen, Jian Ma, Changbin Yin, Ju Huang, Lixin Peng, Zhen Fu, Qilu Song, Fei Lu, Xiangqi Zhang, Yuling Jiao.
Plant Cell, 2025, 37(9). [Html]
Near telomere-to-telomere genome of the model plant Physcomitrium patens ( vol 10, pg 327 , 2024)
Guiqi Bi, Shijun Zhao, Jiawei Yao, Huan Wang, Mengkai Zhao, Yuanyuan Sun, Xueren Hou, Fabian B. Haas, Deepti Varshney, Michael Prigge, Stefan A. Rensing, Yuling Jiao, Yingxin Ma, Jianbin Yan, Junbiao Dai.
Nature Plants, 2025, 11(1), p. 145-146. [Html]
Optimal Distributions of Receptors on Arbitrarily Shaped Cell Surfaces
Daoning Wu, Sayun Mao, Jie Lin.
Physical Review Letters, 2025, 135(20). [Html]
Orthogonal RNA replication enables directed evolution and Darwinian adaptation in mammalian cells
Liang Ma, Yihan Lin.
Nature Chemical Biology, 2025, 21(3). [Html]
Painting Peptides With Antimicrobial Potency Through Deep Reinforcement Learning
Ruihan Dong, Qiushi Cao, Chen Song.
Advanced Science, 2025, 12(43). [Html]
Peptide hormone spexin restores beta cell function and improves glycaemic control in mice via regulation of the sodium-potassium pump
Yaojing Jiang, Di Wu, Yunzhi Ni, Ying Liu, Huixia Ren, Shan Liu, Chengfang Pan, Jiarong Dai, Quanya Sun, Anran Ma, Ge Qin, Jiali Qian, Lijin Ji, Hangping Zheng, Chao Tang, Yehong Yang, Changlong Hu, Hao Yin, Yiming Li, Rui Liu.
Diabetologia, 2025. [Html]
Perturbation of calreticulin potentiates CD8+ T cell-mediated antitumor immunity
Kaiyang Tang, Lijian Wu, Yuanzhi Hu, Teng Xue, Yiteng Jin, Xindi Zhou, Ce Luo, Yaoning Zhao, Linjie Tong, Jie Dai, Di Feng, Zexian Zeng, Deng Pan.
Journal of Experimental Medicine, 2025, 222(10). [Html]
Photonic microspheres for high-capacity DNA data storage: Robust, straightforward, and scalable random access via nonfading indexes
Qiu-Jun Liu, Qian Liu, Jie Zhang, Cheng Zhang, Long Qian, Hao Qi, Yue-Sheng Li, Dong-Po Song.
Science Advances, 2025, 11(25). [Html]
A phylogeny-based method in detecting the species-specialized genes in microbes and its application to a marine symbiont bacterium
Xiaolin Zhou, Weijie Li, Siya Xie, Kang Xia, Mei Xiao, Xiaojing Yang, Zhiyuan Li.
Mbio, 2025, 16(12). [Html]
Physical constraints and biological regulations underlie universal osmoresponses
Yiyang Ye, Qirun Wang, Jie Lin.
Elife, 2025, 13. [Html]
PINK1 deficiency permits the development of Lewy body dementia with coexisting Aβ pathology
Tong-Yao Gao, Xu-Zheng Wang, Yu-Han Xie, Tong Wang, Yun-Bi Lu, Lu-Long Huang, Cong Chen, Ming Zhang, Xin Ma, Ya-Ling Chen, Fu-Xiang Liang, Zhi-Ling Lou, Jin-Sheng Li, Yi-Fan Yu, Jian-Bin Wu, Xiao-Ru Ma, Hua-Li Wang, Chun Tang, Wei-Ping Zhang.
Alzheimers & Dementia, 2025, 21(9). [Html]
Positional BMP signaling orchestrates villus length in the small intestine
Xu Wang, Siqi Li, Yuan Liu, Xiangyu Kuang, Jianxin Chen, Pei Yu, Lianzheng Zhao, Ze Zhang, Meimei Huang, Liansheng Liu, Mengxian Zhang, Yalong Wang, Weizhi Ji, Jinsong Li, Lei Zhang, Ye-Guang Chen.
Nature Communications, 2025, 16(1). [Html]
Positive-going hybrid indicators for voltage imaging in excitable cells and tissues
Shuzhang Liu, Jing Ling, Beichen Xie, Yuan Zhang, Luxin Peng, Luming Yang, Yi Yu, Junye Lin, Chao Tang, Zhixing Chen, Peng Zou.
Science Advances, 2025, 11(32). [Html]
Potential Activation Mechanism of Calcium Indicator WHaloCaMP1a Revealed by the Crystal Structure and Molecular Dynamics Simulations
Kecheng Zhang, Nanhao Chen, Junwei Zhang, Zhixing Chen.
Biochemistry, 2025, 64(19), p. 4254-4262. [Html]
Potentiating anti-tumor immunity by re-engaging immune synapse molecules
Xindi Zhou, Tian Xu, Changhe Li, Yufeng He, Yuanzhi Hu, Hao Gong, Jiahui Li, Haitao Jiang, Liang Wen, Yangxin Fu, Zexian Zeng, Deng Pan.
Cell Reports Medicine, 2025, 6(3). [Html]
Rapaprotin, an Endopeptidase-Activated Proteasome Inhibitor that Induces 26S Disassembly
Hanjing Peng, Zufeng Guo, Wei Li Wang, Deyao Yin, Shitao Zou, Thomas Asbell, Brett R. Ullman, Maya Thakar, Feiran Zhang, Sam Y. Hong, A. V. Subba Rao, Kunyu Wang, Shuwen Zhang, Zhaolong Wu, Xuemei Li, Aidan A. Kendra, Seth S. Margolis, William H. Matsui, Christian B. Gocke, Youdong Mao, Jun O. Liu.
Angewandte Chemie-International Edition, 2025, 64(46). [Html]
Reinforcement Learning-Based Target-Specific De Novo Design of Cyclic Peptide Binders
Fanhao Wang, Tiantian Zhang, Jintao Zhu, Xiaoling Zhang, Changsheng Zhang, Luhua Lai.
Journal of Medicinal Chemistry, 2025, 68(16), p. 17287-17302. [Html]
RNF112 Facilitates Ubiquitin-Mediated Degradation of c-Myc, Suppressing Proliferation, Migration and Lipid Synthesis in Bladder Cancer
Kangping Xiong, Siming Chen, Huimin Xu, Sheng Tu, Hong Weng, Yejinpeng Wang, Mingxing Li, Jingtian Yu, Kaiyu Qian, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Gang Wang.
Advanced Science, 2025, 12(20). [Html]
SecY translocon chaperones protein folding during membrane protein insertion
Xiaomin Ou, Chengying Ma, Dongjie Sun, Jinkun Xu, Yang Wang, Xiaofei Wu, Dali Wang, Song Yang, Ning Gao, Chen Song, Long Li.
Cell, 2025, 188(7), p. 1912-1924. [Html]
Self-organized criticality driven by droplet influx and random fusion
Bohan Lyu, Jie Lin.
Physical Review Research, 2025, 7(2). [Html]
Semi-supervised contrastive learning variational autoencoder Integrating single-cell multimodal mosaic datasets
Zihao Wang, Zeyu Wu, Minghua Deng.
Bmc Bioinformatics, 2025, 26(1). [Html]
Sequence and Structure-based Prediction of Allosteric Sites
Juan Xie, Gaoxiang Pan, Luhua Lai.
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