Monday July 4
08:30-08:40 Welcome Remarks
Session I Chairman: Feng Gai（UPenn）
08:40-09:40 Michael Levitt（Stanford University）
Using Toys Models to Explore the Protein Universe
09:40-10:15 Ruhong Zhou（IBM/Columbia U）
Dewetting Transition and Hydrophobic Collapse in Protein Aggregates
10:15-10:35 Tea Break
10:35-11:10 Martin Gruebele（UIUC）
Downhill Folding on Rough Free Energy Surfaces: physics and evolution at work
11:10-11:45 Hiroshi Kihara (Kansai Medical U)
Alpha-helix-rich folding core of beta-sheeted proteins
12:00-13:30 Lunch
Session II Chairman: Valerie Daggett（University of Washington）
13:30-14:05 Huanxiang Zhou(Florida State University)
Electrostatic Interactions in Unfolded, Folded, Complexed, and Transition States of Proteins
14:05-14:40 Jianpeng Ma (Baylor/Rice)
New Methods for Simulating Protein Dynamics at Multi-resolution and Multi-length Scales
14:40-15:15 Hue Sun Chan（Toronto U）
Desolvation is a Likely Origin of Robust Enthalpic Barriers to Cooperative Protein Folding
15:15-15:50 Jin Wang (SUNY Stony Brook)
Diffusion Dynamics of Protein Folding
15:50-16:10 Tea Break
Session III Chairman: Yunyu Shi （USTC）
16:10-16:45 Junmei Zhou （Inst. Of Biophysics, CAS）
Molecular Chaperone Function of Escherichia coli Trigger Factor
16:45-17:20 Yi Liang（Wuhan University）
Mixed Macromolecular Crowding Accelerates the Oxidative Refolding of Reduced, Denatured Lysozyme: Implications for Protein Folding in Intracellular Environments
17:20-17:55 Changwen Jin (PKU)
Solution Structures and Functional Insights of an Arsenate Reductase from Bacillus subtilis: Reversible Conformational Switch Associates with the Arsenate Reduction
Tuesday, July 5
Session I Chairman: Jeff Saven (UPenn)
08:30-09:30 Alan Fersht（Cambridge University）
How Small Proteins Fold
09:30-10:05 Yunyu Shi （USTC）
Protein structure and protein-protein interaction studied by NMR
10:05-10:25 Tea Break
10:25-11:00 Valerie Daggett（University of Washington）
Protein Unfolding and Refolding at Atomic Resolution
11:00-11:35 Yong Duan （UC Davis）
Folding and aggregation: A physics-based all-atom modeling
11:35-11:50 Sarah Perrett （Inst. Of Biophysics, CAS）
Factors influencing the function, folding and fibril formation of the yeast prion protein ure2
12:00-13:30 Lunch
Session II Chairman: Chih-Chen Wang（Inst. Of Biophysics, CAS）
13:30-14:05 Feng Gai（UPenn）
Understanding the Folding Mechanism of b-Hairpins
14:05-14:40 Yongzhang Luo（Tsinghua U）
Refolding of Proteins from in vitro to in vivo
14:40-15:15 Zengyi Chang (PKU)
Immediate response to stress conditions for the structure and activity of molecular Chaperones
15:15-15:50 Chi-Ming Chen (National Taiwan Normal University, Taiwan)
Structure Prediction and Folding Dynamics of Bacteriorhodopsin
15:50-16:10 Tea Break
Session III Chairman: Luhua Lai（PKU）
16:10-16:25 Yuguang Mu (Nanyang Technological University, Singapore; ShanDong University,China)
Intermediate states of forming binding protein WW domain: explored by replica-exchange simulation
16:25-16:40 Fan Jiang (Institute of Physics, CAS)
Scaling laws in folding of native protein structures
16:40-16:55 Bin Lai (Stony Brook University)
Translocation of Diphtheria Toxin T Domain-Induced Translocation of the Diphtheria Toxin Catalytic Domain (A Chain) Across Membranes: Role of Changes in Protein Folding/Unfolding
16:55-17:10 Rongzheng Wan (Shanghai Institute of Applied Physics, CAS)
Controllable water channel gating of nanometer dimensions
17:10-17:25 Ming Lei (Beijing University of Chemical Technology)
Role of conformational change in initial partial disrupted path of V14N/V16E mutant of transthyretin: Insights from molecular dynamic simulation
17:25-17:40 Xiaohong Shi (Huazhong University of Sciences and Technology)
A Finding Maximal Clique Algorithm for predicting Loop of Protein Structure
17:40-17:55 Ying-Chieh Sun(National Taiwan Normal University, Taiwan)
Examination of Several Factors Affecting Folding of Short Helical Peptides Using Molecular Dynamics Simulation
Wednesday July 6
Session I Chairman: Zengyi Chang（PKU）
08:30-09:30 Chih-Chen Wang（Inst. Of Biophysics, CAS）
Dimerization and chaperone activity of thiol-protein oxidoreductases
09:30-10:05 Yawen Bai （NIH）
Hidden Intermediates at Atomic Resolution: Implications for Protein Folding
10:05-10:25 Tea Break
10:25-11:00 Wei Wang (Nanjing U)
Folding of small proteins using simplified Go-model and all-atom model
11:00-11:35 Emily Ching（Chinese U of HK）
Characteristic patterns in amino acid sequences and their use in the prediction of protein structures
11:35-11:50 Aoneng Cao（PKU）
Mechanism of the folding and chaperone-like activity of the small heat shock protein rom Methanococcus jannaschii
12:00-13:30 Lunch
13:30-15:00 Poster Session
Tuesday July 7
Session I Chairman: Ruhong Zhou（IBM/Columbia U）
08:30-09:30 William Degrado（UPenn）
De Novo design of Catalytic Proteins
09:30-10:05 Chao Tang (UCSF/PKU)
Flexibility of secondary structures from database analysis
10:05-10:25 Tea Break
10:25-11:00 Yaoqi Zhou (SUNY Buffalo)
Molecular mechanism of binding cooperativity in a dimeric hemoglobin
11:00-11:35 Ray Luo (UC Irvine)
Unfolding and refolding of p53 cancer and suppressor mutations
11:35-11:50 Jingyuan Li （Zhejiang University）
Hydration and Dewetting near Graphite-CH3 and Graphite-COOH Plates
12:00-13:30 Lunch
Session II Chairman: Chao Tang（UCSF/PKU）
13:30-14:05 Jeff Saven (UPenn)
Methods for engineering protein structure and function with computational protein design
14:05-14:40 Chen Zeng (George Washington U)
Application of Generic Sidechains and Softmodes in Protein Design
14:40-15:15 Hong Qian (U. of Washington)
Dynamics on Energy Landscapes: From Protein Folding Pathways to Open-systems Thermodynamics of Kinetic Proofreading
15:15-15:50 Luhua Lai （PKU）
Functional Protein Design Targeting Protein-Protein Interface
