韩敬东



博士生导师

电话:010-62757330
邮箱:jackie.han@pku.edu.cn           

实验室主页:https://cqb.pku.edu.cn/hanlab

1991年毕业于中国药科大学获药理学学士学位
1996年毕业于美国爱因斯坦医学院获生物医学科学专业博士学位



担任职务:

北京大学定量生物学中心教授

北京大学-清华大学生命科学联合中心教授

研究方向:

分子系统生物学

研究兴趣:

本课题组主要从事分子系统生物学研究工作,具体包括:
1.研究生物网络的结构、动态及其功能;
2.通过表观组学、功能基因组学及整合网络分析,寻找衰老及干细胞分化相关的关键基因,并进一步研究分子及功能作用机制;
3.探求遗传基因网络中内在的安全稳定机制。

工作经历:

2019-7-至今  北京大学前沿交叉学科研究院,教授

2010.09-2019.06,中科院计算生物学重点实验室,主任.

2010.09-2019.06,中科院上海生科院计算生物学研究所,所长、研究员.

2005.03-2010.08,中科院遗传与发育生物学研究所,分子系统中心主任,研究员.

2002.09-2005.03,美国哈佛大学医学院,博士后.

2001.07-2002.08,美国CQOS公司,工程师.

2000.07-2001.06,美国Rare Medium公司,软件开发.

1999.01-2000.06,美国NorthStar科技公司,工程师.

1997.06-1998.12,美国洛克菲勒大学,博士后.


代表性文章:

1.  Na Sun^, Xiaoming Yu^, Fang Li^, Denghui Liu, Shengbao Suo, Weiyang Chen, Shirui Chen, Lu Song, Christopher D. Green, Joseph McDermott, Qin Shen, Naihe Jing & Jing-Dong J. Han. Inference of differentiation time for single cell transcriptomes using cell population reference data. Nature Communications. 2017 Nov 30;8(1):1856        

2.  Xinyi Wang^, Denghui Liu^, Dajian He, Shengbao Suo, Xian Xia, Xiechao He, Jing-Dong J. Han*, and Ping Zheng*. Transcriptome analyses of rhesus monkey preimplantation embryos reveal a reduced capacity for DNA double-strand break repair in primate oocytes and early embryos. Genome Research. 2017 Apr;27(4):567-579. doi: 10.1101/gr.198044.115. Epub 2017 Feb 21.

3.  Guangdun Peng^, Shengbao Suo^, Jun Chen^, Weiyang Chen, Chang Liu, Fang Yu, Ran Wang, Shirui Chen, Na Sun, Guizhong Cui, Lu Song, Patrick P.L. Tam, Jing-Dong J. Han*, Naihe Jing*. Spatial Transcriptome for the Molecular Annotation of Lineage Fates and Cell Identity in Mid-gastrula Mouse Embryo. Developmental Cell, 2016 Mar 21;36(6):681-97. doi: 10.1016/j.devcel.2016.02.020.

4.  Lei Hou, Dan Wang, Di Chen, Yi Liu, Yue Zhang, Hao Cheng, Chi Xu, Na Sun, Joseph McDermott, and William B. Mair and Jing-Dong J. Han*. A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction. Cell Metabolism, 2016, 8;23(3):529-40.

5.  Yi Huang, Xiaoming Yu, Na Sun, Nan Qiao, Yaqiang Cao, Jerome D. Boyd-Kirkup, Qin Shen, and Jing-Dong J Han. Single-cell level spatial gene expression in the embryonic neural differentiation niche. Genome Research. 2015 Apr;25(4):570-81.

6.  Weiyang Chen, Wei Qian, Gang Wu, Weizhong Chen, Bo Xian, Xingwei Chen, Yaqiang Cao, Christopher D Green, Fanghong Zhao, Kun Tang and Jing-Dong J. Han*, Three-dimensional human facial morphologies as robust aging markers, Cell Research, 2015, 25:574-587 (highlighted by Nature Press Release, Science News, New Scientists, The Guardian, Daily Mail, and NewsWeek, etc).

7.  Weizhong Chen, Yi Liu, Shanshan Zhu, Christopher D. Green, Gang Wei, Jing-Dong J. Han*, Improved Nucleosome Positioning Algorithm iNPS for Accurate Nucleosome Positioning from Sequencing Data, Nature Communications 2014, doi:10.1038/ncomms5909.

8.  Ming Su, Dali Han, Jerome D Boyd-Kirkup, Xiaoming Yu and Jing-Dong J Han*,Evolution of Alu towards enhancers, Cell Reports, 2014, 7(2): 376-385

9.  Jin’e Li, Yi Liu, Min Liu and Jing-Dong J Han*,Functional dissection of regulatory models using gene expression data of deletion mutants, PLoS Genetics, 2013, 9(9): e1003757.

10.  Wei Zhang, Yi Liu, Na Sun, Dan Wang, Jerome Boyd-Kirkup, Xiaoyang Dou, Jing-Dong J Han*, Integrating Genomic, Epigenomic and Transcriptomic Features Reveals Modular Signatures Underlying Poor Prognosis in Ovarian Cancer, Cell Reports, 2013, 4(3):542–553

11.  Yi Liu, Nan Qiao, Shanshan Zhu, Ming Su, Na Sun, Jerome Boyd-Kirkup, Jing-Dong J. Han*. A novel Bayesian network inference algorithm for integrative analysis of heterogeneous deep sequencing data. Cell Research. 2013 Mar;23(3):440-3.

12.  Zhou, B., Yang, L., Li, S.F., Huang, J.L., Chen, H.Y., Hou, L., Wang, J.B., Green, C.D., Yan, Z., Huang, X., Zhu L., Xiao H.S., Liu Y. *, and Han J.D.J. * (2012). Midlife Gene Expressions Identify Modulators of Aging through Dietary Interventions, Proc Natl Acad Sci U S A. 8;109(19):E1201-9.

13.   Jin, C., Li, J., Green, C.D., Yu, X. , Tang, X, Han, D., Xian, Bo., Wang, D, Huang, X., Cao, X., Yan. Z., Hou, L., Liu, J., Shukeir, N., Khaitovich, P., Chen, C.D., Zhang, H., Jenuwein, T. and  Han, J.-D.J *, Histone Demethylase UTX-1 Regulates C. elegans Lifespan by Targeting Insulin/IGF-1 Signaling Pathway, Cell Metabolism, 2011, 14: 16

 

获奖情况:

2018年  十大科技进展

2016年  Faculty 1000 in Developmental Biology

2015年  中科院分子细胞卓越中心

2015年  上海市领军人才

2015年  国家百千万人才工程有突出贡献中青年

2014年  MaxNetAging Fellow

2011年  Max Planck Fellow

2010年  中科院百人计划终期评估优秀

2007年  教育部技术奖

2006年  国家杰出青年

2005年  中科院百人计划

1998年  National Institute of Health (NIH)博士后奖学金获得者

1997年  Howard Hughes Medical Institute (HHMI) 博士后奖学金获得者